Development of Potent and Metabolically Stable APJ Ligands with High Therapeutic Potential.

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Title: Development of Potent and Metabolically Stable APJ Ligands with High Therapeutic Potential.
Authors: Juhl C; Department of Medicinal Chemistry, Bayer Pharma AG, Aprather Weg 18 A, 42096, Wuppertal, Germany., Els-Heindl S; Institute of Biochemistry, Leipzig University, Brüderstraße 34, 04103, Leipzig, Germany., Schönauer R; Institute of Biochemistry, Leipzig University, Brüderstraße 34, 04103, Leipzig, Germany., Redlich G; Global External Innovation & Alliances, Bayer Pharma AG, Aprather Weg 18 A, 42096, Wuppertal, Germany., Haaf E; Department of Pharmacokinetics and Metabolism, Bayer Pharma AG, Aprather Weg 18 A, 42096, Wuppertal, Germany., Wunder F; Lead Discovery Wuppertal, Bayer Pharma AG, Aprather Weg 18 A, 42096, Wuppertal, Germany., Riedl B; Department of Medicinal Chemistry, Bayer Pharma AG, Aprather Weg 18 A, 42096, Wuppertal, Germany., Burkhardt N; Lead Discovery Wuppertal, Bayer Pharma AG, Aprather Weg 18 A, 42096, Wuppertal, Germany., Beck-Sickinger AG; Institute of Biochemistry, Leipzig University, Brüderstraße 34, 04103, Leipzig, Germany., Bierer D; Department of Medicinal Chemistry, Bayer Pharma AG, Aprather Weg 18 A, 42096, Wuppertal, Germany.
Source: ChemMedChem [ChemMedChem] 2016 Nov 07; Vol. 11 (21), pp. 2378-2384. Date of Electronic Publication: 2016 Aug 25.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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ISSN:1860-7187
DOI:10.1002/cmdc.201600307