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Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus.

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Title: Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus.
Authors: Yang SW; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States. Electronic address: shu-wei.yang@merck.com., Pan J; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States., Yang C; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States., Labroli M; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States., Pan W; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States., Caldwell J; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States., Ha S; Structure Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States., Koseoglu S; In Vitro Pharmacology Group, Merck Research Laboratory, Kenilworth, NJ 07033, United States., Xiao JC; In Vitro Pharmacology Group, Merck Research Laboratory, Kenilworth, NJ 07033, United States., Mayhood T; In Vitro Pharmacology Group, Merck Research Laboratory, Kenilworth, NJ 07033, United States., Sheth PR; In Vitro Pharmacology Group, Merck Research Laboratory, Kenilworth, NJ 07033, United States., Garlisi CG; In Vitro Pharmacology Group, Merck Research Laboratory, Kenilworth, NJ 07033, United States., Wu J; Pharmacokinetics PPDM, Merck Research Laboratory, Kenilworth, NJ 07033, United States., Lee SH; Infectious Disease, Merck Research Laboratory, Kenilworth, NJ 07033, United States., Wang H; Infectious Disease, Merck Research Laboratory, Kenilworth, NJ 07033, United States., Tan CM; Infectious Disease, Merck Research Laboratory, Kenilworth, NJ 07033, United States., Roemer T; Infectious Disease, Merck Research Laboratory, Kenilworth, NJ 07033, United States., Su J; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Oct 01; Vol. 26 (19), pp. 4743-4747. Date of Electronic Publication: 2016 Aug 16.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus.
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  Data: <searchLink fieldCode="AU" term="%22Yang+SW%22">Yang SW</searchLink>; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States. Electronic address: shu-wei.yang@merck.com.<br /><searchLink fieldCode="AU" term="%22Pan+J%22">Pan J</searchLink>; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States.<br /><searchLink fieldCode="AU" term="%22Yang+C%22">Yang C</searchLink>; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States.<br /><searchLink fieldCode="AU" term="%22Labroli+M%22">Labroli M</searchLink>; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States.<br /><searchLink fieldCode="AU" term="%22Pan+W%22">Pan W</searchLink>; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States.<br /><searchLink fieldCode="AU" term="%22Caldwell+J%22">Caldwell J</searchLink>; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States.<br /><searchLink fieldCode="AU" term="%22Ha+S%22">Ha S</searchLink>; Structure Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States.<br /><searchLink fieldCode="AU" term="%22Koseoglu+S%22">Koseoglu S</searchLink>; In Vitro Pharmacology Group, Merck Research Laboratory, Kenilworth, NJ 07033, United States.<br /><searchLink fieldCode="AU" term="%22Xiao+JC%22">Xiao JC</searchLink>; In Vitro Pharmacology Group, Merck Research Laboratory, Kenilworth, NJ 07033, United States.<br /><searchLink fieldCode="AU" term="%22Mayhood+T%22">Mayhood T</searchLink>; In Vitro Pharmacology Group, Merck Research Laboratory, Kenilworth, NJ 07033, United States.<br /><searchLink fieldCode="AU" term="%22Sheth+PR%22">Sheth PR</searchLink>; In Vitro Pharmacology Group, Merck Research Laboratory, Kenilworth, NJ 07033, United States.<br /><searchLink fieldCode="AU" term="%22Garlisi+CG%22">Garlisi CG</searchLink>; In Vitro Pharmacology Group, Merck Research Laboratory, Kenilworth, NJ 07033, United States.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Pharmacokinetics PPDM, Merck Research Laboratory, Kenilworth, NJ 07033, United States.<br /><searchLink fieldCode="AU" term="%22Lee+SH%22">Lee SH</searchLink>; Infectious Disease, Merck Research Laboratory, Kenilworth, NJ 07033, United States.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Infectious Disease, Merck Research Laboratory, Kenilworth, NJ 07033, United States.<br /><searchLink fieldCode="AU" term="%22Tan+CM%22">Tan CM</searchLink>; Infectious Disease, Merck Research Laboratory, Kenilworth, NJ 07033, United States.<br /><searchLink fieldCode="AU" term="%22Roemer+T%22">Roemer T</searchLink>; Infectious Disease, Merck Research Laboratory, Kenilworth, NJ 07033, United States.<br /><searchLink fieldCode="AU" term="%22Su+J%22">Su J</searchLink>; Discovery Chemistry, Merck Research Laboratory, Kenilworth, NJ 07033, United States.
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        Value: 10.1016/j.bmcl.2016.08.036
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