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Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.

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Title: Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.
Authors: Mayers JR; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. These authors contributed equally to this work., Torrence ME; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. These authors contributed equally to this work., Danai LV; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Papagiannakopoulos T; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Davidson SM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Bauer MR; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Lau AN; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Ji BW; Center for Computational Biology and Bioinformatics and Department of Systems Biology, Columbia University, New York, NY 10027, USA., Dixit PD; Center for Computational Biology and Bioinformatics and Department of Systems Biology, Columbia University, New York, NY 10027, USA., Hosios AM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Muir A; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Chin CR; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Freinkman E; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA. Broad Institute, Seven Cambridge Center, Cambridge, MA 02142, USA. Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Jacks T; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Wolpin BM; Dana-Farber Cancer Institute, Boston, MA 02115, USA., Vitkup D; Center for Computational Biology and Bioinformatics and Department of Systems Biology, Columbia University, New York, NY 10027, USA., Vander Heiden MG; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Broad Institute, Seven Cambridge Center, Cambridge, MA 02142, USA. Dana-Farber Cancer Institute, Boston, MA 02115, USA. mvh@mit.edu.
Source: Science (New York, N.Y.) [Science] 2016 Sep 09; Vol. 353 (6304), pp. 1161-5.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
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  Data: Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.
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  Data: <searchLink fieldCode="AU" term="%22Mayers+JR%22">Mayers JR</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. These authors contributed equally to this work.<br /><searchLink fieldCode="AU" term="%22Torrence+ME%22">Torrence ME</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. These authors contributed equally to this work.<br /><searchLink fieldCode="AU" term="%22Danai+LV%22">Danai LV</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Papagiannakopoulos+T%22">Papagiannakopoulos T</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Davidson+SM%22">Davidson SM</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Bauer+MR%22">Bauer MR</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Lau+AN%22">Lau AN</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Ji+BW%22">Ji BW</searchLink>; Center for Computational Biology and Bioinformatics and Department of Systems Biology, Columbia University, New York, NY 10027, USA.<br /><searchLink fieldCode="AU" term="%22Dixit+PD%22">Dixit PD</searchLink>; Center for Computational Biology and Bioinformatics and Department of Systems Biology, Columbia University, New York, NY 10027, USA.<br /><searchLink fieldCode="AU" term="%22Hosios+AM%22">Hosios AM</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Muir+A%22">Muir A</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Chin+CR%22">Chin CR</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Freinkman+E%22">Freinkman E</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142, USA. Broad Institute, Seven Cambridge Center, Cambridge, MA 02142, USA. Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Jacks+T%22">Jacks T</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.<br /><searchLink fieldCode="AU" term="%22Wolpin+BM%22">Wolpin BM</searchLink>; Dana-Farber Cancer Institute, Boston, MA 02115, USA.<br /><searchLink fieldCode="AU" term="%22Vitkup+D%22">Vitkup D</searchLink>; Center for Computational Biology and Bioinformatics and Department of Systems Biology, Columbia University, New York, NY 10027, USA.<br /><searchLink fieldCode="AU" term="%22Vander+Heiden+MG%22">Vander Heiden MG</searchLink>; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Broad Institute, Seven Cambridge Center, Cambridge, MA 02142, USA. Dana-Farber Cancer Institute, Boston, MA 02115, USA. mvh@mit.edu.
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