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Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression.

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Title: Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression.
Authors: Roy B; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655-0122.; PTC Therapeutics Inc., South Plainfield, NJ 07080., Friesen WJ; PTC Therapeutics Inc., South Plainfield, NJ 07080., Tomizawa Y; PTC Therapeutics Inc., South Plainfield, NJ 07080., Leszyk JD; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655-0122., Zhuo J; PTC Therapeutics Inc., South Plainfield, NJ 07080., Johnson B; PTC Therapeutics Inc., South Plainfield, NJ 07080., Dakka J; PTC Therapeutics Inc., South Plainfield, NJ 07080., Trotta CR; PTC Therapeutics Inc., South Plainfield, NJ 07080., Xue X; PTC Therapeutics Inc., South Plainfield, NJ 07080.; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294.; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL 35294., Mutyam V; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL 35294.; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294., Keeling KM; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294.; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL 35294., Mobley JA; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294., Rowe SM; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL 35294.; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294., Bedwell DM; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294.; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL 35294., Welch EM; PTC Therapeutics Inc., South Plainfield, NJ 07080., Jacobson A; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655-0122; allan.jacobson@umassmed.edu.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Nov 01; Vol. 113 (44), pp. 12508-12513. Date of Electronic Publication: 2016 Oct 04.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Ataluren stimulates ribosomal selection of near-cognate tRNAs to promote nonsense suppression.
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  Data: <searchLink fieldCode="AU" term="%22Roy+B%22">Roy B</searchLink>; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655-0122.; PTC Therapeutics Inc., South Plainfield, NJ 07080.<br /><searchLink fieldCode="AU" term="%22Friesen+WJ%22">Friesen WJ</searchLink>; PTC Therapeutics Inc., South Plainfield, NJ 07080.<br /><searchLink fieldCode="AU" term="%22Tomizawa+Y%22">Tomizawa Y</searchLink>; PTC Therapeutics Inc., South Plainfield, NJ 07080.<br /><searchLink fieldCode="AU" term="%22Leszyk+JD%22">Leszyk JD</searchLink>; Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01655-0122.<br /><searchLink fieldCode="AU" term="%22Zhuo+J%22">Zhuo J</searchLink>; PTC Therapeutics Inc., South Plainfield, NJ 07080.<br /><searchLink fieldCode="AU" term="%22Johnson+B%22">Johnson B</searchLink>; PTC Therapeutics Inc., South Plainfield, NJ 07080.<br /><searchLink fieldCode="AU" term="%22Dakka+J%22">Dakka J</searchLink>; PTC Therapeutics Inc., South Plainfield, NJ 07080.<br /><searchLink fieldCode="AU" term="%22Trotta+CR%22">Trotta CR</searchLink>; PTC Therapeutics Inc., South Plainfield, NJ 07080.<br /><searchLink fieldCode="AU" term="%22Xue+X%22">Xue X</searchLink>; PTC Therapeutics Inc., South Plainfield, NJ 07080.; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294.; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL 35294.<br /><searchLink fieldCode="AU" term="%22Mutyam+V%22">Mutyam V</searchLink>; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL 35294.; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.<br /><searchLink fieldCode="AU" term="%22Keeling+KM%22">Keeling KM</searchLink>; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294.; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL 35294.<br /><searchLink fieldCode="AU" term="%22Mobley+JA%22">Mobley JA</searchLink>; Department of Surgery, University of Alabama at Birmingham, Birmingham, AL 35294.<br /><searchLink fieldCode="AU" term="%22Rowe+SM%22">Rowe SM</searchLink>; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL 35294.; Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294.<br /><searchLink fieldCode="AU" term="%22Bedwell+DM%22">Bedwell DM</searchLink>; Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294.; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, AL 35294.<br /><searchLink fieldCode="AU" term="%22Welch+EM%22">Welch EM</searchLink>; PTC Therapeutics Inc., South Plainfield, NJ 07080.<br /><searchLink fieldCode="AU" term="%22Jacobson+A%22">Jacobson A</searchLink>; Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA 01655-0122; allan.jacobson@umassmed.edu.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2016 Nov 01; Vol. 113 (44), pp. 12508-12513. <i>Date of Electronic Publication: </i>2016 Oct 04.
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