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A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation.

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Title: A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation.
Authors: Petersen DN; Medicine Design, Worldwide Research & Development, Pfizer, Inc., Eastern Point Road, Groton, CT 06340, USA., Hawkins J; Cardiovascular and Metabolic Diseases Research Unit, Worldwide Research & Development, Pfizer, Inc., 610 Main Street, Cambridge, MA 02139, USA., Ruangsiriluk W; Cardiovascular and Metabolic Diseases Research Unit, Worldwide Research & Development, Pfizer, Inc., 610 Main Street, Cambridge, MA 02139, USA., Stevens KA; Cardiovascular and Metabolic Diseases Research Unit, Worldwide Research & Development, Pfizer, Inc., 610 Main Street, Cambridge, MA 02139, USA., Maguire BA; Medicine Design, Worldwide Research & Development, Pfizer, Inc., Eastern Point Road, Groton, CT 06340, USA., O'Connell TN; Medicine Design, Worldwide Research & Development, Pfizer, Inc., Eastern Point Road, Groton, CT 06340, USA., Rocke BN; Medicine Design, Worldwide Research & Development, Pfizer, Inc., Eastern Point Road, Groton, CT 06340, USA., Boehm M; Medicine Design, Worldwide Research & Development, Pfizer, Inc., 610 Main Street, Cambridge, MA 02139, USA., Ruggeri RB; Medicine Design, Worldwide Research & Development, Pfizer, Inc., Eastern Point Road, Groton, CT 06340, USA., Rolph T; Cardiovascular and Metabolic Diseases Research Unit, Worldwide Research & Development, Pfizer, Inc., 610 Main Street, Cambridge, MA 02139, USA., Hepworth D; Medicine Design, Worldwide Research & Development, Pfizer, Inc., 610 Main Street, Cambridge, MA 02139, USA., Loria PM; Medicine Design, Worldwide Research & Development, Pfizer, Inc., Eastern Point Road, Groton, CT 06340, USA. Electronic address: paula.m.loria@pfizer.com., Carpino PA; Medicine Design, Worldwide Research & Development, Pfizer, Inc., 610 Main Street, Cambridge, MA 02139, USA. Electronic address: philip.a.carpino@pfizer.com.
Source: Cell chemical biology [Cell Chem Biol] 2016 Nov 17; Vol. 23 (11), pp. 1362-1371. Date of Electronic Publication: 2016 Oct 13.
Publication Type: Journal Article
Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE
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