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Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set.

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Title: Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set.
Authors: Roszik J; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA. jroszik@mdanderson.org.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. jroszik@mdanderson.org., Haydu LE; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Hess KR; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Oba J; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA., Joon AY; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Siroy AE; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Karpinets TV; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Stingo FC; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Baladandayuthapani V; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Tetzlaff MT; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Wargo JA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Chen K; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Forget MA; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA., Haymaker CL; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA., Chen JQ; Lion Biotechnologies, Woodland Hills, CA, 91637, USA., Meric-Bernstam F; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, 770393, USA., Eterovic AK; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Shaw KR; Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, 770393, USA., Mills GB; Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, 770393, USA.; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Gershenwald JE; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Radvanyi LG; EMD Serono, Rockland, MA, 02370, USA., Hwu P; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA., Futreal PA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Gibbons DL; Department of Thoracic Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Lazar AJ; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Bernatchez C; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA., Davies MA; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA.; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Woodman SE; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA. swoodman@mdanderson.org.; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. swoodman@mdanderson.org.
Source: BMC medicine [BMC Med] 2016 Oct 25; Vol. 14 (1), pp. 168. Date of Electronic Publication: 2016 Oct 25.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set.
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  Data: <searchLink fieldCode="AU" term="%22Roszik+J%22">Roszik J</searchLink>; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA. jroszik@mdanderson.org.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. jroszik@mdanderson.org.<br /><searchLink fieldCode="AU" term="%22Haydu+LE%22">Haydu LE</searchLink>; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Hess+KR%22">Hess KR</searchLink>; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Oba+J%22">Oba J</searchLink>; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Joon+AY%22">Joon AY</searchLink>; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Siroy+AE%22">Siroy AE</searchLink>; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Karpinets+TV%22">Karpinets TV</searchLink>; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Stingo+FC%22">Stingo FC</searchLink>; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Baladandayuthapani+V%22">Baladandayuthapani V</searchLink>; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Tetzlaff+MT%22">Tetzlaff MT</searchLink>; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Wargo+JA%22">Wargo JA</searchLink>; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Chen+K%22">Chen K</searchLink>; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Forget+MA%22">Forget MA</searchLink>; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Haymaker+CL%22">Haymaker CL</searchLink>; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Chen+JQ%22">Chen JQ</searchLink>; Lion Biotechnologies, Woodland Hills, CA, 91637, USA.<br /><searchLink fieldCode="AU" term="%22Meric-Bernstam+F%22">Meric-Bernstam F</searchLink>; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, 770393, USA.<br /><searchLink fieldCode="AU" term="%22Eterovic+AK%22">Eterovic AK</searchLink>; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Shaw+KR%22">Shaw KR</searchLink>; Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, 770393, USA.<br /><searchLink fieldCode="AU" term="%22Mills+GB%22">Mills GB</searchLink>; Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, 770393, USA.; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Gershenwald+JE%22">Gershenwald JE</searchLink>; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Radvanyi+LG%22">Radvanyi LG</searchLink>; EMD Serono, Rockland, MA, 02370, USA.<br /><searchLink fieldCode="AU" term="%22Hwu+P%22">Hwu P</searchLink>; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Futreal+PA%22">Futreal PA</searchLink>; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Gibbons+DL%22">Gibbons DL</searchLink>; Department of Thoracic Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Lazar+AJ%22">Lazar AJ</searchLink>; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Bernatchez+C%22">Bernatchez C</searchLink>; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Davies+MA%22">Davies MA</searchLink>; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA.; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.<br /><searchLink fieldCode="AU" term="%22Woodman+SE%22">Woodman SE</searchLink>; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA. swoodman@mdanderson.org.; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. swoodman@mdanderson.org.
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