Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set.

Saved in:
Bibliographic Details
Title: Novel algorithmic approach predicts tumor mutation load and correlates with immunotherapy clinical outcomes using a defined gene mutation set.
Authors: Roszik J; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA. jroszik@mdanderson.org.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. jroszik@mdanderson.org., Haydu LE; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Hess KR; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Oba J; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA., Joon AY; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Siroy AE; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Karpinets TV; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Stingo FC; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Baladandayuthapani V; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Tetzlaff MT; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Wargo JA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Chen K; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Forget MA; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA., Haymaker CL; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA., Chen JQ; Lion Biotechnologies, Woodland Hills, CA, 91637, USA., Meric-Bernstam F; Department of Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, 770393, USA., Eterovic AK; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Shaw KR; Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, 770393, USA., Mills GB; Sheikh Khalifa Bin Zayed Al Nahyan Institute for Personalized Cancer Therapy, The University of Texas MD Anderson Cancer Center, Houston, TX, 770393, USA.; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Gershenwald JE; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Radvanyi LG; EMD Serono, Rockland, MA, 02370, USA., Hwu P; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA., Futreal PA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Gibbons DL; Department of Thoracic Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Lazar AJ; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Bernatchez C; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA., Davies MA; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA.; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Woodman SE; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd., Unit 904, Houston, TX, 77030, USA. swoodman@mdanderson.org.; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. swoodman@mdanderson.org.
Source: BMC medicine [BMC Med] 2016 Oct 25; Vol. 14 (1), pp. 168. Date of Electronic Publication: 2016 Oct 25.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1741-7015
DOI:10.1186/s12916-016-0705-4