Histopathological regression after neoadjuvant docetaxel, oxaliplatin, fluorouracil, and leucovorin versus epirubicin, cisplatin, and fluorouracil or capecitabine in patients with resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4-AIO): results from the phase 2 part of a multicentre, open-label, randomised phase 2/3 trial.
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| Title: | Histopathological regression after neoadjuvant docetaxel, oxaliplatin, fluorouracil, and leucovorin versus epirubicin, cisplatin, and fluorouracil or capecitabine in patients with resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4-AIO): results from the phase 2 part of a multicentre, open-label, randomised phase 2/3 trial. |
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| Authors: | Al-Batran SE; Institute of Clinical Cancer Research, UCT University Cancer Center, Krankenhaus Nordwest, Frankfurt, Germany. Electronic address: albatran.salah@khnw.de., Hofheinz RD; Medical Department III, Universitätsmedizin Mannheim, Mannheim, Germany., Pauligk C; Institute of Clinical Cancer Research, UCT University Cancer Center, Krankenhaus Nordwest, Frankfurt, Germany., Kopp HG; Medical Department II, University Hospital, Tübingen, Germany., Haag GM; National Center for Tumor Diseases, University Hospital Heidelberg, Medical Oncology, Heidelberg, Germany., Luley KB; Universitätsklinikum Schleswig-Holstein, Medical Department I Hematology/Oncology, Lübeck, Germany., Meiler J; West German Cancer Center, Department of Medical Oncology, and German Cancer Consortium (DKTK), University Hospital Essen, Essen, Germany., Homann N; Klinikum Wolfsburg, Medical Department II, Wolfsburg, Germany., Lorenzen S; Klinikum rechts der Isar der TU München, Medical Department III, Munich, Germany., Schmalenberg H; Department of Internal Medicine II, University Hospital Jena, Germany., Probst S; Klinikum Bielefeld, Department for Hematology and Oncology, Bielefeld, Germany., Koenigsmann M; MediProjekt, Gesellschaft für Medizinstatistik und Projektentwicklung, Hannover, Germany., Egger M; Ortenau Klinikum Lahr, Medical Department, Lahr, Germany., Prasnikar N; Klinikum Ludwigsburg, Medical Department I, Ludwigsburg, Germany., Caca K; Klinikum Ludwigsburg, Medical Department I, Ludwigsburg, Germany., Trojan J; Medical Department I, Goethe University Medical Center, Frankfurt, Germany., Martens UM; SLK-Kliniken, Medical Department III, Cancer Center Heilbronn-Franken, Heilbronn, Germany., Block A; University Hospital Hamburg-Eppendorf, Department for Oncology and Hematology, Hamburg, Germany., Fischbach W; Klinikum Aschaffenburg, Medical Department II, Aschaffenburg, Germany., Mahlberg R; Klinikum Mutterhaus der Borromäerinnen, Medical Department I, Trier, Germany., Clemens M; Klinikum Mutterhaus der Borromäerinnen, Medical Department I, Trier, Germany., Illerhaus G; Universitätsklinikum Freiburg, Medical Department I, Freiburg, Germany., Zirlik K; Universitätsklinikum Freiburg, Medical Department I, Freiburg, Germany., Behringer DM; Augusta-Krankenanstalt, Department for Hematology, Oncology and Palliative Medicine, Bochum, Germany., Schmiegel W; Department of Internal Medicine, Ruhr-University Bochum, Bochum, Germany., Pohl M; Department of Internal Medicine, Ruhr-University Bochum, Bochum, Germany., Heike M; Klinikum Dortmund, Medical Department, Dortmund, Germany., Ronellenfitsch U; Department of Surgery, Universitätsmedizin Mannheim, Mannheim, Germany., Schuler M; West German Cancer Center, Department of Medical Oncology, and German Cancer Consortium (DKTK), University Hospital Essen, Essen, Germany., Bechstein WO; Department of General and Visceral Surgery, Goethe University Medical Center, Frankfurt, Germany., Königsrainer A; Department of Surgery and Transplantation, University Hospital, Tübingen, Germany., Gaiser T; Department of Pathology, Universitätsmedizin Mannheim, Mannheim, Germany., Schirmacher P; Institute of Pathology, University Hospital Heidelberg, Medical Oncology, Heidelberg, Germany., Hozaeel W; Institute of Clinical Cancer Research, UCT University Cancer Center, Krankenhaus Nordwest, Frankfurt, Germany., Reichart A; Institute of Clinical Cancer Research, UCT University Cancer Center, Krankenhaus Nordwest, Frankfurt, Germany., Goetze TO; Institute of Clinical Cancer Research, UCT University Cancer Center, Krankenhaus Nordwest, Frankfurt, Germany., Sievert M; Sanofi Genzymy, Berlin, Germany., Jäger E; Department of Hematology-Oncology, Krankenhaus Nordwest, Frankfurt, Germany., Mönig S; Hôpitaux Universitaires de Genève, Service de Chirurgie Viscérale, Geneva, Switzerland., Tannapfel A; Institute for Pathology, Ruhr-University Bochum, Bochum, Germany. |
| Source: | The Lancet. Oncology [Lancet Oncol] 2016 Dec; Vol. 17 (12), pp. 1697-1708. Date of Electronic Publication: 2016 Oct 22. |
| Publication Type: | Clinical Trial, Phase II; Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial |
| Journal Info: | Publisher: Lancet Pub. Group Country of Publication: England NLM ID: 100957246 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1474-5488 (Electronic) Linking ISSN: 14702045 NLM ISO Abbreviation: Lancet Oncol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 27776843 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Histopathological regression after neoadjuvant docetaxel, oxaliplatin, fluorouracil, and leucovorin versus epirubicin, cisplatin, and fluorouracil or capecitabine in patients with resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4-AIO): results from the phase 2 part of a multicentre, open-label, randomised phase 2/3 trial. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Al-Batran+SE%22">Al-Batran SE</searchLink>; Institute of Clinical Cancer Research, UCT University Cancer Center, Krankenhaus Nordwest, Frankfurt, Germany. Electronic address: albatran.salah@khnw.de.<br /><searchLink fieldCode="AU" term="%22Hofheinz+RD%22">Hofheinz RD</searchLink>; Medical Department III, Universitätsmedizin Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Pauligk+C%22">Pauligk C</searchLink>; Institute of Clinical Cancer Research, UCT University Cancer Center, Krankenhaus Nordwest, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Kopp+HG%22">Kopp HG</searchLink>; Medical Department II, University Hospital, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Haag+GM%22">Haag GM</searchLink>; National Center for Tumor Diseases, University Hospital Heidelberg, Medical Oncology, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Luley+KB%22">Luley KB</searchLink>; Universitätsklinikum Schleswig-Holstein, Medical Department I Hematology/Oncology, Lübeck, Germany.<br /><searchLink fieldCode="AU" term="%22Meiler+J%22">Meiler J</searchLink>; West German Cancer Center, Department of Medical Oncology, and German Cancer Consortium (DKTK), University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Homann+N%22">Homann N</searchLink>; Klinikum Wolfsburg, Medical Department II, Wolfsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Lorenzen+S%22">Lorenzen S</searchLink>; Klinikum rechts der Isar der TU München, Medical Department III, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Schmalenberg+H%22">Schmalenberg H</searchLink>; Department of Internal Medicine II, University Hospital Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Probst+S%22">Probst S</searchLink>; Klinikum Bielefeld, Department for Hematology and Oncology, Bielefeld, Germany.<br /><searchLink fieldCode="AU" term="%22Koenigsmann+M%22">Koenigsmann M</searchLink>; MediProjekt, Gesellschaft für Medizinstatistik und Projektentwicklung, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Egger+M%22">Egger M</searchLink>; Ortenau Klinikum Lahr, Medical Department, Lahr, Germany.<br /><searchLink fieldCode="AU" term="%22Prasnikar+N%22">Prasnikar N</searchLink>; Klinikum Ludwigsburg, Medical Department I, Ludwigsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Caca+K%22">Caca K</searchLink>; Klinikum Ludwigsburg, Medical Department I, Ludwigsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Trojan+J%22">Trojan J</searchLink>; Medical Department I, Goethe University Medical Center, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Martens+UM%22">Martens UM</searchLink>; SLK-Kliniken, Medical Department III, Cancer Center Heilbronn-Franken, Heilbronn, Germany.<br /><searchLink fieldCode="AU" term="%22Block+A%22">Block A</searchLink>; University Hospital Hamburg-Eppendorf, Department for Oncology and Hematology, Hamburg, Germany.<br /><searchLink fieldCode="AU" term="%22Fischbach+W%22">Fischbach W</searchLink>; Klinikum Aschaffenburg, Medical Department II, Aschaffenburg, Germany.<br /><searchLink fieldCode="AU" term="%22Mahlberg+R%22">Mahlberg R</searchLink>; Klinikum Mutterhaus der Borromäerinnen, Medical Department I, Trier, Germany.<br /><searchLink fieldCode="AU" term="%22Clemens+M%22">Clemens M</searchLink>; Klinikum Mutterhaus der Borromäerinnen, Medical Department I, Trier, Germany.<br /><searchLink fieldCode="AU" term="%22Illerhaus+G%22">Illerhaus G</searchLink>; Universitätsklinikum Freiburg, Medical Department I, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Zirlik+K%22">Zirlik K</searchLink>; Universitätsklinikum Freiburg, Medical Department I, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Behringer+DM%22">Behringer DM</searchLink>; Augusta-Krankenanstalt, Department for Hematology, Oncology and Palliative Medicine, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Schmiegel+W%22">Schmiegel W</searchLink>; Department of Internal Medicine, Ruhr-University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Pohl+M%22">Pohl M</searchLink>; Department of Internal Medicine, Ruhr-University Bochum, Bochum, Germany.<br /><searchLink fieldCode="AU" term="%22Heike+M%22">Heike M</searchLink>; Klinikum Dortmund, Medical Department, Dortmund, Germany.<br /><searchLink fieldCode="AU" term="%22Ronellenfitsch+U%22">Ronellenfitsch U</searchLink>; Department of Surgery, Universitätsmedizin Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Schuler+M%22">Schuler M</searchLink>; West German Cancer Center, Department of Medical Oncology, and German Cancer Consortium (DKTK), University Hospital Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Bechstein+WO%22">Bechstein WO</searchLink>; Department of General and Visceral Surgery, Goethe University Medical Center, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Königsrainer+A%22">Königsrainer A</searchLink>; Department of Surgery and Transplantation, University Hospital, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Gaiser+T%22">Gaiser T</searchLink>; Department of Pathology, Universitätsmedizin Mannheim, Mannheim, Germany.<br /><searchLink fieldCode="AU" term="%22Schirmacher+P%22">Schirmacher P</searchLink>; Institute of Pathology, University Hospital Heidelberg, Medical Oncology, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hozaeel+W%22">Hozaeel W</searchLink>; Institute of Clinical Cancer Research, UCT University Cancer Center, Krankenhaus Nordwest, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Reichart+A%22">Reichart A</searchLink>; Institute of Clinical Cancer Research, UCT University Cancer Center, Krankenhaus Nordwest, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Goetze+TO%22">Goetze TO</searchLink>; Institute of Clinical Cancer Research, UCT University Cancer Center, Krankenhaus Nordwest, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Sievert+M%22">Sievert M</searchLink>; Sanofi Genzymy, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Jäger+E%22">Jäger E</searchLink>; Department of Hematology-Oncology, Krankenhaus Nordwest, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Mönig+S%22">Mönig S</searchLink>; Hôpitaux Universitaires de Genève, Service de Chirurgie Viscérale, Geneva, Switzerland.<br /><searchLink fieldCode="AU" term="%22Tannapfel+A%22">Tannapfel A</searchLink>; Institute for Pathology, Ruhr-University Bochum, Bochum, Germany. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22100957246%22">The Lancet. Oncology</searchLink> [Lancet Oncol] 2016 Dec; Vol. 17 (12), pp. 1697-1708. <i>Date of Electronic Publication: </i>2016 Oct 22. – Name: TypePub Label: Publication Type Group: TypPub Data: Clinical Trial, Phase II; Clinical Trial, Phase III; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Lancet+Pub%2E+Group%22">Lancet Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>100957246 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1474-5488 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214702045%22">14702045 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Oncol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=27776843 |
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