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The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients.

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Title: The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients.
Authors: Kennedy ME; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA. matthew.kennedy@merck.com andy.stamford1@gmail.com ericmcparker@comcast.net mark.forman@merck.com., Stamford AW; Department of Global Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA. matthew.kennedy@merck.com andy.stamford1@gmail.com ericmcparker@comcast.net mark.forman@merck.com., Chen X; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Cox K; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Cumming JN; Department of Global Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Dockendorf MF; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Egan M; Department of Clinical Research, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Ereshefsky L; PAREXEL, Glendale, CA 91206, USA., Hodgson RA; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Hyde LA; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Jhee S; PAREXEL, Glendale, CA 91206, USA., Kleijn HJ; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Kuvelkar R; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Li W; Department of Global Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Mattson BA; Department of Safety Assessment, Merck Research Laboratories, West Point, PA 19446, USA., Mei H; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Palcza J; Department of Biostatistics, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Scott JD; Department of Global Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Tanen M; Translational Biomarkers Department, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Troyer MD; Department of Translational Medicine, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Tseng JL; Department of Translational Medicine, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Stone JA; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA., Parker EM; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA. matthew.kennedy@merck.com andy.stamford1@gmail.com ericmcparker@comcast.net mark.forman@merck.com., Forman MS; Department of Translational Medicine, Merck Research Laboratories, Kenilworth, NJ 07033, USA. matthew.kennedy@merck.com andy.stamford1@gmail.com ericmcparker@comcast.net mark.forman@merck.com.
Source: Science translational medicine [Sci Transl Med] 2016 Nov 02; Vol. 8 (363), pp. 363ra150.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: The BACE1 inhibitor verubecestat (MK-8931) reduces CNS β-amyloid in animal models and in Alzheimer's disease patients.
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  Data: <searchLink fieldCode="AU" term="%22Kennedy+ME%22">Kennedy ME</searchLink>; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA. matthew.kennedy@merck.com andy.stamford1@gmail.com ericmcparker@comcast.net mark.forman@merck.com.<br /><searchLink fieldCode="AU" term="%22Stamford+AW%22">Stamford AW</searchLink>; Department of Global Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA. matthew.kennedy@merck.com andy.stamford1@gmail.com ericmcparker@comcast.net mark.forman@merck.com.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Cox+K%22">Cox K</searchLink>; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Cumming+JN%22">Cumming JN</searchLink>; Department of Global Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Dockendorf+MF%22">Dockendorf MF</searchLink>; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Egan+M%22">Egan M</searchLink>; Department of Clinical Research, Merck Research Laboratories, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Ereshefsky+L%22">Ereshefsky L</searchLink>; PAREXEL, Glendale, CA 91206, USA.<br /><searchLink fieldCode="AU" term="%22Hodgson+RA%22">Hodgson RA</searchLink>; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Hyde+LA%22">Hyde LA</searchLink>; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Jhee+S%22">Jhee S</searchLink>; PAREXEL, Glendale, CA 91206, USA.<br /><searchLink fieldCode="AU" term="%22Kleijn+HJ%22">Kleijn HJ</searchLink>; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Kuvelkar+R%22">Kuvelkar R</searchLink>; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Department of Global Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Mattson+BA%22">Mattson BA</searchLink>; Department of Safety Assessment, Merck Research Laboratories, West Point, PA 19446, USA.<br /><searchLink fieldCode="AU" term="%22Mei+H%22">Mei H</searchLink>; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Palcza+J%22">Palcza J</searchLink>; Department of Biostatistics, Merck Research Laboratories, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Scott+JD%22">Scott JD</searchLink>; Department of Global Chemistry, Merck Research Laboratories, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Tanen+M%22">Tanen M</searchLink>; Translational Biomarkers Department, Merck Research Laboratories, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Troyer+MD%22">Troyer MD</searchLink>; Department of Translational Medicine, Merck Research Laboratories, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Tseng+JL%22">Tseng JL</searchLink>; Department of Translational Medicine, Merck Research Laboratories, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Stone+JA%22">Stone JA</searchLink>; Department of Pharmacokinetics, Pharmacodynamics and Drug Metabolism, Merck Research Laboratories, Kenilworth, NJ 07033, USA.<br /><searchLink fieldCode="AU" term="%22Parker+EM%22">Parker EM</searchLink>; Department of Neuroscience, Merck Research Laboratories, Kenilworth, NJ 07033, USA. matthew.kennedy@merck.com andy.stamford1@gmail.com ericmcparker@comcast.net mark.forman@merck.com.<br /><searchLink fieldCode="AU" term="%22Forman+MS%22">Forman MS</searchLink>; Department of Translational Medicine, Merck Research Laboratories, Kenilworth, NJ 07033, USA. matthew.kennedy@merck.com andy.stamford1@gmail.com ericmcparker@comcast.net mark.forman@merck.com.
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