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siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.

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Title: siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.
Authors: Elkayam E; Keck Structural Biology Lab, Cold Spring Harbor, NY 11724, USA.; Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724, USA.; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA., Parmar R; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA., Brown CR; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA., Willoughby JL; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA., Theile CS; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA., Manoharan M; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA., Joshua-Tor L; Keck Structural Biology Lab, Cold Spring Harbor, NY 11724, USA.; Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724, USA.; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Source: Nucleic acids research [Nucleic Acids Res] 2017 Apr 07; Vol. 45 (6), pp. 3528-3536.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.
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  Data: <searchLink fieldCode="AU" term="%22Elkayam+E%22">Elkayam E</searchLink>; Keck Structural Biology Lab, Cold Spring Harbor, NY 11724, USA.; Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724, USA.; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.<br /><searchLink fieldCode="AU" term="%22Parmar+R%22">Parmar R</searchLink>; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Brown+CR%22">Brown CR</searchLink>; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Willoughby+JL%22">Willoughby JL</searchLink>; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Theile+CS%22">Theile CS</searchLink>; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Manoharan+M%22">Manoharan M</searchLink>; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.<br /><searchLink fieldCode="AU" term="%22Joshua-Tor+L%22">Joshua-Tor L</searchLink>; Keck Structural Biology Lab, Cold Spring Harbor, NY 11724, USA.; Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724, USA.; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
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        Value: 10.1093/nar/gkw1171
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              Text: 2017 Apr 07
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