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Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease.

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Title: Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease.
Authors: Ghosh A; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA., Tyson T; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA., George S; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA., Hildebrandt EN; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA., Steiner JA; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA., Madaj Z; Bioinformatics and Biostatistics Core, Van Andel Research Institute, Grand Rapids, MI 49503, USA., Schulz E; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA., Machiela E; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA., McDonald WG; Metabolic Solutions Development Company, Kalamazoo, MI 49007, USA., Escobar Galvis ML; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA., Kordower JH; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA.; Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, IL 60612, USA., Van Raamsdonk JM; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA., Colca JR; Metabolic Solutions Development Company, Kalamazoo, MI 49007, USA., Brundin P; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA. patrik.brundin@vai.org.
Source: Science translational medicine [Sci Transl Med] 2016 Dec 07; Vol. 8 (368), pp. 368ra174.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease.
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  Data: <searchLink fieldCode="AU" term="%22Ghosh+A%22">Ghosh A</searchLink>; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA.<br /><searchLink fieldCode="AU" term="%22Tyson+T%22">Tyson T</searchLink>; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA.<br /><searchLink fieldCode="AU" term="%22George+S%22">George S</searchLink>; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA.<br /><searchLink fieldCode="AU" term="%22Hildebrandt+EN%22">Hildebrandt EN</searchLink>; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA.<br /><searchLink fieldCode="AU" term="%22Steiner+JA%22">Steiner JA</searchLink>; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA.<br /><searchLink fieldCode="AU" term="%22Madaj+Z%22">Madaj Z</searchLink>; Bioinformatics and Biostatistics Core, Van Andel Research Institute, Grand Rapids, MI 49503, USA.<br /><searchLink fieldCode="AU" term="%22Schulz+E%22">Schulz E</searchLink>; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA.<br /><searchLink fieldCode="AU" term="%22Machiela+E%22">Machiela E</searchLink>; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA.<br /><searchLink fieldCode="AU" term="%22McDonald+WG%22">McDonald WG</searchLink>; Metabolic Solutions Development Company, Kalamazoo, MI 49007, USA.<br /><searchLink fieldCode="AU" term="%22Escobar+Galvis+ML%22">Escobar Galvis ML</searchLink>; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA.<br /><searchLink fieldCode="AU" term="%22Kordower+JH%22">Kordower JH</searchLink>; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA.; Center for Brain Repair, Department of Pathology, Rush Medical College, Chicago, IL 60612, USA.<br /><searchLink fieldCode="AU" term="%22Van+Raamsdonk+JM%22">Van Raamsdonk JM</searchLink>; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA.<br /><searchLink fieldCode="AU" term="%22Colca+JR%22">Colca JR</searchLink>; Metabolic Solutions Development Company, Kalamazoo, MI 49007, USA.<br /><searchLink fieldCode="AU" term="%22Brundin+P%22">Brundin P</searchLink>; Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids, MI 49503, USA. patrik.brundin@vai.org.
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              Text: 2016 Dec 07
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