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Pharmacological Characterization of a Novel Beta 3 Adrenergic Agonist, Vibegron: Evaluation of Antimuscarinic Receptor Selectivity for Combination Therapy for Overactive Bladder.

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Title: Pharmacological Characterization of a Novel Beta 3 Adrenergic Agonist, Vibegron: Evaluation of Antimuscarinic Receptor Selectivity for Combination Therapy for Overactive Bladder.
Authors: Di Salvo J; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey jerry.disalvo@evotec.com., Nagabukuro H; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Wickham LA; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Abbadie C; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., DeMartino JA; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Fitzmaurice A; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Gichuru L; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Kulick A; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Donnelly MJ; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Jochnowitz N; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Hurley AL; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Pereira A; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Sanfiz A; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Veronin G; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Villa K; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Woods J; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Zamlynny B; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Zycband E; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Salituro GM; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Frenkl T; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Weber AE; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Edmondson SD; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey., Struthers M; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.
Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2017 Feb; Vol. 360 (2), pp. 346-355. Date of Electronic Publication: 2016 Dec 13.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Di+Salvo+J%22">Di Salvo J</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey jerry.disalvo@evotec.com.<br /><searchLink fieldCode="AU" term="%22Nagabukuro+H%22">Nagabukuro H</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Wickham+LA%22">Wickham LA</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Abbadie+C%22">Abbadie C</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22DeMartino+JA%22">DeMartino JA</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Fitzmaurice+A%22">Fitzmaurice A</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Gichuru+L%22">Gichuru L</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Kulick+A%22">Kulick A</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Donnelly+MJ%22">Donnelly MJ</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Jochnowitz+N%22">Jochnowitz N</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Hurley+AL%22">Hurley AL</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Pereira+A%22">Pereira A</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Sanfiz+A%22">Sanfiz A</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Veronin+G%22">Veronin G</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Villa+K%22">Villa K</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Woods+J%22">Woods J</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Zamlynny+B%22">Zamlynny B</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Zycband+E%22">Zycband E</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Salituro+GM%22">Salituro GM</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Frenkl+T%22">Frenkl T</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Weber+AE%22">Weber AE</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Edmondson+SD%22">Edmondson SD</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.<br /><searchLink fieldCode="AU" term="%22Struthers+M%22">Struthers M</searchLink>; Discovery and Preclinical Sciences, Merck Research Laboratories, Kenilworth, New Jersey.
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  Data: <searchLink fieldCode="JN" term="%220376362%22">The Journal of pharmacology and experimental therapeutics</searchLink> [J Pharmacol Exp Ther] 2017 Feb; Vol. 360 (2), pp. 346-355. <i>Date of Electronic Publication: </i>2016 Dec 13.
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