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PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.

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Title: PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.
Authors: Anderson GR; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Wardell SE; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Cakir M; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.; Program in Computational Biology and Bioinformatics, Duke University, Durham, NC 27708, USA., Crawford L; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.; Department of Statistical Science, Duke University, Durham, NC 27708, USA., Leeds JC; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Nussbaum DP; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.; Department of Surgery, Duke University, Durham, NC 27710, USA., Shankar PS; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Soderquist RS; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Stein EM; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Tingley JP; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Winter PS; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.; Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA., Zieser-Misenheimer EK; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Alley HM; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Yllanes A; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Haney V; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Blackwell KL; Department of Medicine/Oncology, Duke University, Durham, NC 27710, USA., McCall SJ; Department of Pathology, Duke University, Durham, NC 27710, USA., McDonnell DP; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Wood KC; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA. kris.wood@duke.edu.
Source: Science translational medicine [Sci Transl Med] 2016 Dec 14; Vol. 8 (369), pp. 369ra175.
Publication Type: Journal Article
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.
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  Data: <searchLink fieldCode="AU" term="%22Anderson+GR%22">Anderson GR</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Wardell+SE%22">Wardell SE</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Cakir+M%22">Cakir M</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.; Program in Computational Biology and Bioinformatics, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Crawford+L%22">Crawford L</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.; Department of Statistical Science, Duke University, Durham, NC 27708, USA.<br /><searchLink fieldCode="AU" term="%22Leeds+JC%22">Leeds JC</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Nussbaum+DP%22">Nussbaum DP</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.; Department of Surgery, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Shankar+PS%22">Shankar PS</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Soderquist+RS%22">Soderquist RS</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Stein+EM%22">Stein EM</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Tingley+JP%22">Tingley JP</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Winter+PS%22">Winter PS</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.; Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Zieser-Misenheimer+EK%22">Zieser-Misenheimer EK</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Alley+HM%22">Alley HM</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Yllanes+A%22">Yllanes A</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Haney+V%22">Haney V</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Blackwell+KL%22">Blackwell KL</searchLink>; Department of Medicine/Oncology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22McCall+SJ%22">McCall SJ</searchLink>; Department of Pathology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22McDonnell+DP%22">McDonnell DP</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.<br /><searchLink fieldCode="AU" term="%22Wood+KC%22">Wood KC</searchLink>; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA. kris.wood@duke.edu.
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