PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.
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| Title: | PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation. |
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| Authors: | Anderson GR; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Wardell SE; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Cakir M; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.; Program in Computational Biology and Bioinformatics, Duke University, Durham, NC 27708, USA., Crawford L; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.; Department of Statistical Science, Duke University, Durham, NC 27708, USA., Leeds JC; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Nussbaum DP; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.; Department of Surgery, Duke University, Durham, NC 27710, USA., Shankar PS; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Soderquist RS; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Stein EM; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Tingley JP; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Winter PS; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA.; Program in Genetics and Genomics, Duke University, Durham, NC 27710, USA., Zieser-Misenheimer EK; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Alley HM; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Yllanes A; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Haney V; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Blackwell KL; Department of Medicine/Oncology, Duke University, Durham, NC 27710, USA., McCall SJ; Department of Pathology, Duke University, Durham, NC 27710, USA., McDonnell DP; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA., Wood KC; Department of Pharmacology and Cancer Biology, Duke University, Durham, NC 27710, USA. kris.wood@duke.edu. |
| Source: | Science translational medicine [Sci Transl Med] 2016 Dec 14; Vol. 8 (369), pp. 369ra175. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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