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Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.

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Title: Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.
Authors: Lingel A; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Sendzik M; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Huang Y; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Shultz MD; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Cantwell J; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Dillon MP; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Fu X; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Fuller J; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Gabriel T; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Gu J; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Jiang X; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Li L; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Liang F; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., McKenna M; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Qi W; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Rao W; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Sheng X; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Shu W; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Sutton J; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Taft B; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Wang L; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Zeng J; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Zhang H; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Zhang M; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Zhao K; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Lindvall M; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Bussiere DE; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2017 Jan 12; Vol. 60 (1), pp. 415-427. Date of Electronic Publication: 2017 Jan 03.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1520-4804
DOI:10.1021/acs.jmedchem.6b01473