View in EDS

Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.

Saved in:
Bibliographic Details
Title: Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.
Authors: Lingel A; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Sendzik M; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Huang Y; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Shultz MD; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Cantwell J; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Dillon MP; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Fu X; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Fuller J; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Gabriel T; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Gu J; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Jiang X; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Li L; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Liang F; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., McKenna M; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Qi W; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Rao W; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Sheng X; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Shu W; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Sutton J; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Taft B; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Wang L; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Zeng J; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Zhang H; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Zhang M; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Zhao K; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Lindvall M; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Bussiere DE; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2017 Jan 12; Vol. 60 (1), pp. 415-427. Date of Electronic Publication: 2017 Jan 03.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 27992714
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Lingel+A%22">Lingel A</searchLink>; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Sendzik+M%22">Sendzik M</searchLink>; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Huang+Y%22">Huang Y</searchLink>; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Shultz+MD%22">Shultz MD</searchLink>; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Cantwell+J%22">Cantwell J</searchLink>; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Dillon+MP%22">Dillon MP</searchLink>; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Fu+X%22">Fu X</searchLink>; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Fuller+J%22">Fuller J</searchLink>; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Gabriel+T%22">Gabriel T</searchLink>; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Gu+J%22">Gu J</searchLink>; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Jiang+X%22">Jiang X</searchLink>; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Li+L%22">Li L</searchLink>; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Liang+F%22">Liang F</searchLink>; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22McKenna+M%22">McKenna M</searchLink>; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Qi+W%22">Qi W</searchLink>; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Rao+W%22">Rao W</searchLink>; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Sheng+X%22">Sheng X</searchLink>; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Shu+W%22">Shu W</searchLink>; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Sutton+J%22">Sutton J</searchLink>; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Taft+B%22">Taft B</searchLink>; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zeng+J%22">Zeng J</searchLink>; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhang+H%22">Zhang H</searchLink>; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Zhao+K%22">Zhao K</searchLink>; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China.<br /><searchLink fieldCode="AU" term="%22Lindvall+M%22">Lindvall M</searchLink>; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.<br /><searchLink fieldCode="AU" term="%22Bussiere+DE%22">Bussiere DE</searchLink>; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2017 Jan 12; Vol. 60 (1), pp. 415-427. <i>Date of Electronic Publication: </i>2017 Jan 03.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=27992714
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acs.jmedchem.6b01473
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 415
    Titles:
      – TitleFull: Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Lingel A
      – PersonEntity:
          Name:
            NameFull: Sendzik M
      – PersonEntity:
          Name:
            NameFull: Huang Y
      – PersonEntity:
          Name:
            NameFull: Shultz MD
      – PersonEntity:
          Name:
            NameFull: Cantwell J
      – PersonEntity:
          Name:
            NameFull: Dillon MP
      – PersonEntity:
          Name:
            NameFull: Fu X
      – PersonEntity:
          Name:
            NameFull: Fuller J
      – PersonEntity:
          Name:
            NameFull: Gabriel T
      – PersonEntity:
          Name:
            NameFull: Gu J
      – PersonEntity:
          Name:
            NameFull: Jiang X
      – PersonEntity:
          Name:
            NameFull: Li L
      – PersonEntity:
          Name:
            NameFull: Liang F
      – PersonEntity:
          Name:
            NameFull: McKenna M
      – PersonEntity:
          Name:
            NameFull: Qi W
      – PersonEntity:
          Name:
            NameFull: Rao W
      – PersonEntity:
          Name:
            NameFull: Sheng X
      – PersonEntity:
          Name:
            NameFull: Shu W
      – PersonEntity:
          Name:
            NameFull: Sutton J
      – PersonEntity:
          Name:
            NameFull: Taft B
      – PersonEntity:
          Name:
            NameFull: Wang L
      – PersonEntity:
          Name:
            NameFull: Zeng J
      – PersonEntity:
          Name:
            NameFull: Zhang H
      – PersonEntity:
          Name:
            NameFull: Zhang M
      – PersonEntity:
          Name:
            NameFull: Zhao K
      – PersonEntity:
          Name:
            NameFull: Lindvall M
      – PersonEntity:
          Name:
            NameFull: Bussiere DE
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 12
              M: 01
              Text: 2017 Jan 12
              Type: published
              Y: 2017
          Identifiers:
            – Type: issn-electronic
              Value: 1520-4804
          Numbering:
            – Type: volume
              Value: 60
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Journal of medicinal chemistry
              Type: main
ResultId 1