Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.
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| Title: | Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase. |
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| Authors: | Lingel A; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Sendzik M; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Huang Y; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Shultz MD; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Cantwell J; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Dillon MP; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Fu X; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Fuller J; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Gabriel T; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Gu J; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Jiang X; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Li L; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Liang F; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., McKenna M; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Qi W; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Rao W; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Sheng X; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Shu W; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Sutton J; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Taft B; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Wang L; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Zeng J; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Zhang H; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Zhang M; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Zhao K; Novartis Institutes for BioMedical Research , 2418 Jinke Road, Shanghai 201203, China., Lindvall M; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States., Bussiere DE; Novartis Institutes for BioMedical Research , 5300 Chiron Way, Emeryville, California 94608, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2017 Jan 12; Vol. 60 (1), pp. 415-427. Date of Electronic Publication: 2017 Jan 03. |
| Publication Type: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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