HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation. - Myant KB; Cammareri P; Hodder MC; Wills J; Von Kriegsheim A; Győrffy B; Rashid M; Polo S; Maspero E; Vaughan L; Gurung B; Barry E; et al. (EMBO molecular medicine, 2017)