View in EDS PDF Full Text

Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.

Saved in:
Bibliographic Details
Title: Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.
Authors: Soethoudt M; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands.; Department of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands., Grether U; Roche Innovation Center Basel, F. Hoffman-La Roche Ltd., Grenzachterstrasse 124, Basel 4070, Switzerland., Fingerle J; Department of Biochemistry, NMI, University Tübingen, Markwiesenstrasse 55, Reutlingen 72770, Germany., Grim TW; Department of Pharmacology and Toxicology, 1220 East Broad Street, PO Box 980613, Richmond, Virginia 23298-0613, USA., Fezza F; Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, Rome 00133, Italy.; European Center for Brain Research/IRCCS Santa Lucia Foundation, via del Fosso del Fiorano 65, Rome 00143, Italy., de Petrocellis L; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, C.N.R., Via Campi Flegrei 34, Comprensorio Olivetti, Pozzuoli 80078, Italy., Ullmer C; Roche Innovation Center Basel, F. Hoffman-La Roche Ltd., Grenzachterstrasse 124, Basel 4070, Switzerland., Rothenhäusler B; Roche Innovation Center Basel, F. Hoffman-La Roche Ltd., Grenzachterstrasse 124, Basel 4070, Switzerland., Perret C; Roche Innovation Center Basel, F. Hoffman-La Roche Ltd., Grenzachterstrasse 124, Basel 4070, Switzerland., van Gils N; Department of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands., Finlay D; Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, 85 Park road, Grafton, Auckland 1023, New Zealand., MacDonald C; Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, 85 Park road, Grafton, Auckland 1023, New Zealand., Chicca A; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, Bern CH-3012, Switzerland., Gens MD; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, Bern CH-3012, Switzerland., Stuart J; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, New South Wales 2109, Australia., de Vries H; Department of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands., Mastrangelo N; Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, Rome 00128, Italy., Xia L; Department of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands., Alachouzos G; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands., Baggelaar MP; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands., Martella A; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands.; Department of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands., Mock ED; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands., Deng H; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands., Heitman LH; Department of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands., Connor M; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, New South Wales 2109, Australia., Di Marzo V; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, C.N.R., Via Campi Flegrei 34, Comprensorio Olivetti, Pozzuoli 80078, Italy., Gertsch J; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, Bern CH-3012, Switzerland., Lichtman AH; Department of Pharmacology and Toxicology, 1220 East Broad Street, PO Box 980613, Richmond, Virginia 23298-0613, USA., Maccarrone M; European Center for Brain Research/IRCCS Santa Lucia Foundation, via del Fosso del Fiorano 65, Rome 00143, Italy.; Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, Rome 00128, Italy., Pacher P; Laboratory of Cardiovascular Physiology and Tissue Injury, National Institute of Health/NIAAA, 5625 Fishers Lane, Rockville, Maryland 20852, USA., Glass M; Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, 85 Park road, Grafton, Auckland 1023, New Zealand., van der Stelt M; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands.
Source: Nature communications [Nat Commun] 2017 Jan 03; Vol. 8, pp. 13958. Date of Electronic Publication: 2017 Jan 03.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 28045021
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Cannabinoid CB<subscript>2</subscript> receptor ligand profiling reveals biased signalling and off-target activity.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Soethoudt+M%22">Soethoudt M</searchLink>; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands.; Department of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Grether+U%22">Grether U</searchLink>; Roche Innovation Center Basel, F. Hoffman-La Roche Ltd., Grenzachterstrasse 124, Basel 4070, Switzerland.<br /><searchLink fieldCode="AU" term="%22Fingerle+J%22">Fingerle J</searchLink>; Department of Biochemistry, NMI, University Tübingen, Markwiesenstrasse 55, Reutlingen 72770, Germany.<br /><searchLink fieldCode="AU" term="%22Grim+TW%22">Grim TW</searchLink>; Department of Pharmacology and Toxicology, 1220 East Broad Street, PO Box 980613, Richmond, Virginia 23298-0613, USA.<br /><searchLink fieldCode="AU" term="%22Fezza+F%22">Fezza F</searchLink>; Department of Experimental Medicine and Surgery, Tor Vergata University of Rome, Via Montpellier 1, Rome 00133, Italy.; European Center for Brain Research/IRCCS Santa Lucia Foundation, via del Fosso del Fiorano 65, Rome 00143, Italy.<br /><searchLink fieldCode="AU" term="%22de+Petrocellis+L%22">de Petrocellis L</searchLink>; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, C.N.R., Via Campi Flegrei 34, Comprensorio Olivetti, Pozzuoli 80078, Italy.<br /><searchLink fieldCode="AU" term="%22Ullmer+C%22">Ullmer C</searchLink>; Roche Innovation Center Basel, F. Hoffman-La Roche Ltd., Grenzachterstrasse 124, Basel 4070, Switzerland.<br /><searchLink fieldCode="AU" term="%22Rothenhäusler+B%22">Rothenhäusler B</searchLink>; Roche Innovation Center Basel, F. Hoffman-La Roche Ltd., Grenzachterstrasse 124, Basel 4070, Switzerland.<br /><searchLink fieldCode="AU" term="%22Perret+C%22">Perret C</searchLink>; Roche Innovation Center Basel, F. Hoffman-La Roche Ltd., Grenzachterstrasse 124, Basel 4070, Switzerland.<br /><searchLink fieldCode="AU" term="%22van+Gils+N%22">van Gils N</searchLink>; Department of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Finlay+D%22">Finlay D</searchLink>; Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, 85 Park road, Grafton, Auckland 1023, New Zealand.<br /><searchLink fieldCode="AU" term="%22MacDonald+C%22">MacDonald C</searchLink>; Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, 85 Park road, Grafton, Auckland 1023, New Zealand.<br /><searchLink fieldCode="AU" term="%22Chicca+A%22">Chicca A</searchLink>; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, Bern CH-3012, Switzerland.<br /><searchLink fieldCode="AU" term="%22Gens+MD%22">Gens MD</searchLink>; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, Bern CH-3012, Switzerland.<br /><searchLink fieldCode="AU" term="%22Stuart+J%22">Stuart J</searchLink>; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, New South Wales 2109, Australia.<br /><searchLink fieldCode="AU" term="%22de+Vries+H%22">de Vries H</searchLink>; Department of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Mastrangelo+N%22">Mastrangelo N</searchLink>; Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, Rome 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Xia+L%22">Xia L</searchLink>; Department of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Alachouzos+G%22">Alachouzos G</searchLink>; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Baggelaar+MP%22">Baggelaar MP</searchLink>; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Martella+A%22">Martella A</searchLink>; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands.; Department of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Mock+ED%22">Mock ED</searchLink>; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Deng+H%22">Deng H</searchLink>; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Heitman+LH%22">Heitman LH</searchLink>; Department of Medicinal Chemistry, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands.<br /><searchLink fieldCode="AU" term="%22Connor+M%22">Connor M</searchLink>; Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, New South Wales 2109, Australia.<br /><searchLink fieldCode="AU" term="%22Di+Marzo+V%22">Di Marzo V</searchLink>; Endocannabinoid Research Group, Institute of Biomolecular Chemistry, C.N.R., Via Campi Flegrei 34, Comprensorio Olivetti, Pozzuoli 80078, Italy.<br /><searchLink fieldCode="AU" term="%22Gertsch+J%22">Gertsch J</searchLink>; Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, Bern CH-3012, Switzerland.<br /><searchLink fieldCode="AU" term="%22Lichtman+AH%22">Lichtman AH</searchLink>; Department of Pharmacology and Toxicology, 1220 East Broad Street, PO Box 980613, Richmond, Virginia 23298-0613, USA.<br /><searchLink fieldCode="AU" term="%22Maccarrone+M%22">Maccarrone M</searchLink>; European Center for Brain Research/IRCCS Santa Lucia Foundation, via del Fosso del Fiorano 65, Rome 00143, Italy.; Department of Medicine, Campus Bio-Medico University of Rome, Via Alvaro del Portillo 21, Rome 00128, Italy.<br /><searchLink fieldCode="AU" term="%22Pacher+P%22">Pacher P</searchLink>; Laboratory of Cardiovascular Physiology and Tissue Injury, National Institute of Health/NIAAA, 5625 Fishers Lane, Rockville, Maryland 20852, USA.<br /><searchLink fieldCode="AU" term="%22Glass+M%22">Glass M</searchLink>; Department of Pharmacology and Clinical Pharmacology, Faculty of Medical and Health Sciences, University of Auckland, 85 Park road, Grafton, Auckland 1023, New Zealand.<br /><searchLink fieldCode="AU" term="%22van+der+Stelt+M%22">van der Stelt M</searchLink>; Department of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, Leiden 2333 CC, The Netherlands.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101528555%22">Nature communications</searchLink> [Nat Commun] 2017 Jan 03; Vol. 8, pp. 13958. <i>Date of Electronic Publication: </i>2017 Jan 03.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Group%22">Nature Pub. Group </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101528555 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2041-1723 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220411723%22">20411723 </searchLink><i>NLM ISO Abbreviation: </i>Nat Commun <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=28045021
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1038/ncomms13958
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 13958
    Titles:
      – TitleFull: Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Soethoudt M
      – PersonEntity:
          Name:
            NameFull: Grether U
      – PersonEntity:
          Name:
            NameFull: Fingerle J
      – PersonEntity:
          Name:
            NameFull: Grim TW
      – PersonEntity:
          Name:
            NameFull: Fezza F
      – PersonEntity:
          Name:
            NameFull: de Petrocellis L
      – PersonEntity:
          Name:
            NameFull: Ullmer C
      – PersonEntity:
          Name:
            NameFull: Rothenhäusler B
      – PersonEntity:
          Name:
            NameFull: Perret C
      – PersonEntity:
          Name:
            NameFull: van Gils N
      – PersonEntity:
          Name:
            NameFull: Finlay D
      – PersonEntity:
          Name:
            NameFull: MacDonald C
      – PersonEntity:
          Name:
            NameFull: Chicca A
      – PersonEntity:
          Name:
            NameFull: Gens MD
      – PersonEntity:
          Name:
            NameFull: Stuart J
      – PersonEntity:
          Name:
            NameFull: de Vries H
      – PersonEntity:
          Name:
            NameFull: Mastrangelo N
      – PersonEntity:
          Name:
            NameFull: Xia L
      – PersonEntity:
          Name:
            NameFull: Alachouzos G
      – PersonEntity:
          Name:
            NameFull: Baggelaar MP
      – PersonEntity:
          Name:
            NameFull: Martella A
      – PersonEntity:
          Name:
            NameFull: Mock ED
      – PersonEntity:
          Name:
            NameFull: Deng H
      – PersonEntity:
          Name:
            NameFull: Heitman LH
      – PersonEntity:
          Name:
            NameFull: Connor M
      – PersonEntity:
          Name:
            NameFull: Di Marzo V
      – PersonEntity:
          Name:
            NameFull: Gertsch J
      – PersonEntity:
          Name:
            NameFull: Lichtman AH
      – PersonEntity:
          Name:
            NameFull: Maccarrone M
      – PersonEntity:
          Name:
            NameFull: Pacher P
      – PersonEntity:
          Name:
            NameFull: Glass M
      – PersonEntity:
          Name:
            NameFull: van der Stelt M
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 03
              M: 01
              Text: 2017 Jan 03
              Type: published
              Y: 2017
          Identifiers:
            – Type: issn-electronic
              Value: 2041-1723
          Numbering:
            – Type: volume
              Value: 8
          Titles:
            – TitleFull: Nature communications
              Type: main
ResultId 1