Development of a Novel Vaccine Containing Binary Toxin for the Prevention of Clostridium difficile Disease with Enhanced Efficacy against NAP1 Strains.
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| Title: | Development of a Novel Vaccine Containing Binary Toxin for the Prevention of Clostridium difficile Disease with Enhanced Efficacy against NAP1 Strains. |
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| Authors: | Secore S; Vaccine Basic Research, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America., Wang S; Vaccine Basic Research, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America., Doughtry J; Vaccine Basic Research, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America., Xie J; Vaccine Basic Research, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America., Miezeiewski M; Eurofins Laboratories, Lancaster, Pennsylvania, United States of America., Rustandi RR; Vaccine Analytical Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America., Horton M; Vaccine Basic Research, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America., Xoconostle R; Vaccine Basic Research, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America., Wang B; Vaccine Drug Product Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America., Lancaster C; Vaccine Analytical Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America., Kristopeit A; Vaccine Process Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America., Wang SC; Vaccine Process Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America., Christanti S; Vaccine Process Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America., Vitelli S; Vaccine Analytical Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America., Gentile MP; Vaccine Process Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America., Goerke A; Vaccine Process Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America., Skinner J; Vaccine Basic Research, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America., Strable E; Vaccine Drug Product Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America., Thiriot DS; Vaccine Drug Product Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America., Bodmer JL; Vaccine Basic Research, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America., Heinrichs JH; Vaccine Basic Research, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America. |
| Source: | PloS one [PLoS One] 2017 Jan 26; Vol. 12 (1), pp. e0170640. Date of Electronic Publication: 2017 Jan 26 (Print Publication: 2017). |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 28125650 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Development of a Novel Vaccine Containing Binary Toxin for the Prevention of Clostridium difficile Disease with Enhanced Efficacy against NAP1 Strains. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Secore+S%22">Secore S</searchLink>; Vaccine Basic Research, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Wang+S%22">Wang S</searchLink>; Vaccine Basic Research, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Doughtry+J%22">Doughtry J</searchLink>; Vaccine Basic Research, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Xie+J%22">Xie J</searchLink>; Vaccine Basic Research, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Miezeiewski+M%22">Miezeiewski M</searchLink>; Eurofins Laboratories, Lancaster, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Rustandi+RR%22">Rustandi RR</searchLink>; Vaccine Analytical Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Horton+M%22">Horton M</searchLink>; Vaccine Basic Research, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Xoconostle+R%22">Xoconostle R</searchLink>; Vaccine Basic Research, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Wang+B%22">Wang B</searchLink>; Vaccine Drug Product Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Lancaster+C%22">Lancaster C</searchLink>; Vaccine Analytical Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Kristopeit+A%22">Kristopeit A</searchLink>; Vaccine Process Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Wang+SC%22">Wang SC</searchLink>; Vaccine Process Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Christanti+S%22">Christanti S</searchLink>; Vaccine Process Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Vitelli+S%22">Vitelli S</searchLink>; Vaccine Analytical Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Gentile+MP%22">Gentile MP</searchLink>; Vaccine Process Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Goerke+A%22">Goerke A</searchLink>; Vaccine Process Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Skinner+J%22">Skinner J</searchLink>; Vaccine Basic Research, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Strable+E%22">Strable E</searchLink>; Vaccine Drug Product Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Thiriot+DS%22">Thiriot DS</searchLink>; Vaccine Drug Product Development, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Bodmer+JL%22">Bodmer JL</searchLink>; Vaccine Basic Research, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America.<br /><searchLink fieldCode="AU" term="%22Heinrichs+JH%22">Heinrichs JH</searchLink>; Vaccine Basic Research, Merck Research Laboratories, Merck and Company, Incorporated, West Point, Pennsylvania, United States of America. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101285081%22">PloS one</searchLink> [PLoS One] 2017 Jan 26; Vol. 12 (1), pp. e0170640. <i>Date of Electronic Publication: </i>2017 Jan 26 (<i>Print Publication: </i>2017). – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Public+Library+of+Science%22">Public Library of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101285081 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1932-6203 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219326203%22">19326203 </searchLink><i>NLM ISO Abbreviation: </i>PLoS One <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=28125650 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1371/journal.pone.0170640 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: e0170640 Titles: – TitleFull: Development of a Novel Vaccine Containing Binary Toxin for the Prevention of Clostridium difficile Disease with Enhanced Efficacy against NAP1 Strains. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Secore S – PersonEntity: Name: NameFull: Wang S – PersonEntity: Name: NameFull: Doughtry J – PersonEntity: Name: NameFull: Xie J – PersonEntity: Name: NameFull: Miezeiewski M – PersonEntity: Name: NameFull: Rustandi RR – PersonEntity: Name: NameFull: Horton M – PersonEntity: Name: NameFull: Xoconostle R – PersonEntity: Name: NameFull: Wang B – PersonEntity: Name: NameFull: Lancaster C – PersonEntity: Name: NameFull: Kristopeit A – PersonEntity: Name: NameFull: Wang SC – PersonEntity: Name: NameFull: Christanti S – PersonEntity: Name: NameFull: Vitelli S – PersonEntity: Name: NameFull: Gentile MP – PersonEntity: Name: NameFull: Goerke A – PersonEntity: Name: NameFull: Skinner J – PersonEntity: Name: NameFull: Strable E – PersonEntity: Name: NameFull: Thiriot DS – PersonEntity: Name: NameFull: Bodmer JL – PersonEntity: Name: NameFull: Heinrichs JH IsPartOfRelationships: – BibEntity: Dates: – D: 26 M: 01 Text: 2017 Jan 26 Type: published Y: 2017 Identifiers: – Type: issn-electronic Value: 1932-6203 Numbering: – Type: volume Value: 12 – Type: issue Value: 1 Titles: – TitleFull: PloS one Type: main |
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