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Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders.

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Title: Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders.
Authors: Gomez L; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Massari ME; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Vickers T; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Freestone G; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Vernier W; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Ly K; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Xu R; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., McCarrick M; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Marrone T; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Metz M; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Yan YG; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Yoder ZW; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Lemus R; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Broadbent NJ; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Barido R; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Warren N; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Schmelzer K; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Neul D; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Lee D; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Andersen CB; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Sebring K; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Aertgeerts K; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Zhou X; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Tabatabaei A; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Peters M; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States., Breitenbucher JG; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2017 Mar 09; Vol. 60 (5), pp. 2037-2051. Date of Electronic Publication: 2017 Feb 21.
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Design and Synthesis of Novel and Selective Phosphodiesterase 2 (PDE2a) Inhibitors for the Treatment of Memory Disorders.
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  Data: <searchLink fieldCode="AU" term="%22Gomez+L%22">Gomez L</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Massari+ME%22">Massari ME</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Vickers+T%22">Vickers T</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Freestone+G%22">Freestone G</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Vernier+W%22">Vernier W</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Ly+K%22">Ly K</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Xu+R%22">Xu R</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22McCarrick+M%22">McCarrick M</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Marrone+T%22">Marrone T</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Metz+M%22">Metz M</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Yan+YG%22">Yan YG</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Yoder+ZW%22">Yoder ZW</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Lemus+R%22">Lemus R</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Broadbent+NJ%22">Broadbent NJ</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Barido+R%22">Barido R</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Warren+N%22">Warren N</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Schmelzer+K%22">Schmelzer K</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Neul+D%22">Neul D</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Lee+D%22">Lee D</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Andersen+CB%22">Andersen CB</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Sebring+K%22">Sebring K</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Aertgeerts+K%22">Aertgeerts K</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Zhou+X%22">Zhou X</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Tabatabaei+A%22">Tabatabaei A</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Peters+M%22">Peters M</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.<br /><searchLink fieldCode="AU" term="%22Breitenbucher+JG%22">Breitenbucher JG</searchLink>; Dart Neuroscience LLC, 12278 Scripps Summit Drive, San Diego, California 92131, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2017 Mar 09; Vol. 60 (5), pp. 2037-2051. <i>Date of Electronic Publication: </i>2017 Feb 21.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.jmedchem.6b01793
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