First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288.
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| Title: | First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288. |
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| Authors: | Gee KW; 1 Department of Pharmacology, School of Medicine, University of California Irvine, Irvine, USA., Olincy A; 2 Department of Psychiatry, University of Colorado School of Medicine, Aurora, USA., Kanner R; 3 Anvyl LLC, 18092 Sky Park South, Suite F, Irvine, USA., Johnson L; 2 Department of Psychiatry, University of Colorado School of Medicine, Aurora, USA., Hogenkamp D; 1 Department of Pharmacology, School of Medicine, University of California Irvine, Irvine, USA., Harris J; 2 Department of Psychiatry, University of Colorado School of Medicine, Aurora, USA., Tran M; 1 Department of Pharmacology, School of Medicine, University of California Irvine, Irvine, USA., Edmonds SA; 2 Department of Psychiatry, University of Colorado School of Medicine, Aurora, USA., Sauer W; 4 Division of Cardiology, Department of Medicine, University of Colorado School of Medicine, Aurora, USA., Yoshimura R; 1 Department of Pharmacology, School of Medicine, University of California Irvine, Irvine, USA., Johnstone T; 1 Department of Pharmacology, School of Medicine, University of California Irvine, Irvine, USA., Freedman R; 2 Department of Psychiatry, University of Colorado School of Medicine, Aurora, USA. |
| Source: | Journal of psychopharmacology (Oxford, England) [J Psychopharmacol] 2017 Apr; Vol. 31 (4), pp. 434-441. Date of Electronic Publication: 2017 Feb 15. |
| Publication Type: | Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural |
| Journal Info: | Publisher: Sage Publications Country of Publication: United States NLM ID: 8907828 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1461-7285 (Electronic) Linking ISSN: 02698811 NLM ISO Abbreviation: J Psychopharmacol Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 28196430 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Gee+KW%22">Gee KW</searchLink>; 1 Department of Pharmacology, School of Medicine, University of California Irvine, Irvine, USA.<br /><searchLink fieldCode="AU" term="%22Olincy+A%22">Olincy A</searchLink>; 2 Department of Psychiatry, University of Colorado School of Medicine, Aurora, USA.<br /><searchLink fieldCode="AU" term="%22Kanner+R%22">Kanner R</searchLink>; 3 Anvyl LLC, 18092 Sky Park South, Suite F, Irvine, USA.<br /><searchLink fieldCode="AU" term="%22Johnson+L%22">Johnson L</searchLink>; 2 Department of Psychiatry, University of Colorado School of Medicine, Aurora, USA.<br /><searchLink fieldCode="AU" term="%22Hogenkamp+D%22">Hogenkamp D</searchLink>; 1 Department of Pharmacology, School of Medicine, University of California Irvine, Irvine, USA.<br /><searchLink fieldCode="AU" term="%22Harris+J%22">Harris J</searchLink>; 2 Department of Psychiatry, University of Colorado School of Medicine, Aurora, USA.<br /><searchLink fieldCode="AU" term="%22Tran+M%22">Tran M</searchLink>; 1 Department of Pharmacology, School of Medicine, University of California Irvine, Irvine, USA.<br /><searchLink fieldCode="AU" term="%22Edmonds+SA%22">Edmonds SA</searchLink>; 2 Department of Psychiatry, University of Colorado School of Medicine, Aurora, USA.<br /><searchLink fieldCode="AU" term="%22Sauer+W%22">Sauer W</searchLink>; 4 Division of Cardiology, Department of Medicine, University of Colorado School of Medicine, Aurora, USA.<br /><searchLink fieldCode="AU" term="%22Yoshimura+R%22">Yoshimura R</searchLink>; 1 Department of Pharmacology, School of Medicine, University of California Irvine, Irvine, USA.<br /><searchLink fieldCode="AU" term="%22Johnstone+T%22">Johnstone T</searchLink>; 1 Department of Pharmacology, School of Medicine, University of California Irvine, Irvine, USA.<br /><searchLink fieldCode="AU" term="%22Freedman+R%22">Freedman R</searchLink>; 2 Department of Psychiatry, University of Colorado School of Medicine, Aurora, USA. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%228907828%22">Journal of psychopharmacology (Oxford, England)</searchLink> [J Psychopharmacol] 2017 Apr; Vol. 31 (4), pp. 434-441. <i>Date of Electronic Publication: </i>2017 Feb 15. – Name: TypePub Label: Publication Type Group: TypPub Data: Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Sage+Publications%22">Sage Publications </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8907828 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1461-7285 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2202698811%22">02698811 </searchLink><i>NLM ISO Abbreviation: </i>J Psychopharmacol <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=28196430 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1177/0269881117691590 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 434 Titles: – TitleFull: First in human trial of a type I positive allosteric modulator of alpha7-nicotinic acetylcholine receptors: Pharmacokinetics, safety, and evidence for neurocognitive effect of AVL-3288. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gee KW – PersonEntity: Name: NameFull: Olincy A – PersonEntity: Name: NameFull: Kanner R – PersonEntity: Name: NameFull: Johnson L – PersonEntity: Name: NameFull: Hogenkamp D – PersonEntity: Name: NameFull: Harris J – PersonEntity: Name: NameFull: Tran M – PersonEntity: Name: NameFull: Edmonds SA – PersonEntity: Name: NameFull: Sauer W – PersonEntity: Name: NameFull: Yoshimura R – PersonEntity: Name: NameFull: Johnstone T – PersonEntity: Name: NameFull: Freedman R IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: 2017 Apr Type: published Y: 2017 Identifiers: – Type: issn-electronic Value: 1461-7285 Numbering: – Type: volume Value: 31 – Type: issue Value: 4 Titles: – TitleFull: Journal of psychopharmacology (Oxford, England) Type: main |
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