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High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells.

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Title: High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells.
Authors: Sharma A; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Burridge PW; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Pharmacology and Center for Pharmacogenomics, Northwestern University School of Medicine, Chicago, IL 60611, USA., McKeithan WL; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.; Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA., Serrano R; Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92092, USA., Shukla P; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Sayed N; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Churko JM; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Kitani T; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Wu H; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Holmström A; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Matsa E; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Zhang Y; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Kumar A; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Fan AC; Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Del Álamo JC; Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92092, USA., Wu SM; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Moslehi JJ; Division of Cardiovascular Medicine, Cardio-Oncology Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37212, USA., Mercola M; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA., Wu JC; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. joewu@stanford.edu.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
Source: Science translational medicine [Sci Transl Med] 2017 Feb 15; Vol. 9 (377).
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE
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  Data: High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells.
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  Data: <searchLink fieldCode="AU" term="%22Sharma+A%22">Sharma A</searchLink>; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Burridge+PW%22">Burridge PW</searchLink>; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Department of Pharmacology and Center for Pharmacogenomics, Northwestern University School of Medicine, Chicago, IL 60611, USA.<br /><searchLink fieldCode="AU" term="%22McKeithan+WL%22">McKeithan WL</searchLink>; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.; Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Serrano+R%22">Serrano R</searchLink>; Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92092, USA.<br /><searchLink fieldCode="AU" term="%22Shukla+P%22">Shukla P</searchLink>; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Sayed+N%22">Sayed N</searchLink>; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Churko+JM%22">Churko JM</searchLink>; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Kitani+T%22">Kitani T</searchLink>; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Wu+H%22">Wu H</searchLink>; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Holmström+A%22">Holmström A</searchLink>; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Matsa+E%22">Matsa E</searchLink>; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Zhang+Y%22">Zhang Y</searchLink>; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+A%22">Kumar A</searchLink>; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Fan+AC%22">Fan AC</searchLink>; Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Del+Álamo+JC%22">Del Álamo JC</searchLink>; Department of Mechanical and Aerospace Engineering, University of California, San Diego, La Jolla, CA 92092, USA.<br /><searchLink fieldCode="AU" term="%22Wu+SM%22">Wu SM</searchLink>; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.<br /><searchLink fieldCode="AU" term="%22Moslehi+JJ%22">Moslehi JJ</searchLink>; Division of Cardiovascular Medicine, Cardio-Oncology Program, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37212, USA.<br /><searchLink fieldCode="AU" term="%22Mercola+M%22">Mercola M</searchLink>; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA.<br /><searchLink fieldCode="AU" term="%22Wu+JC%22">Wu JC</searchLink>; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. joewu@stanford.edu.; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.; Division of Cardiology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
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