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Design and synthesis of novel, potent and selective hypoxanthine analogs as adenosine A1 receptor antagonists and their biological evaluation.

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Title: Design and synthesis of novel, potent and selective hypoxanthine analogs as adenosine A1 receptor antagonists and their biological evaluation.
Authors: Koul S; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India. Electronic address: summon.koul@advinus.com., Ramdas V; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Barawkar DA; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Waman YB; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Prasad N; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Madadi SK; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Shejul YD; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Bonagiri R; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Basu S; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Menon S; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Reddy SB; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Chaturvedi S; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Chennamaneni SR; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Bedse G; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Thakare R; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Gundu J; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Chaudhary S; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., De S; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Meru AV; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Palle V; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Chugh A; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Mookhtiar KA; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2017 Mar 15; Vol. 25 (6), pp. 1963-1975. Date of Electronic Publication: 2017 Feb 16.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1464-3391
DOI:10.1016/j.bmc.2017.02.029