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Design and synthesis of novel, potent and selective hypoxanthine analogs as adenosine A1 receptor antagonists and their biological evaluation.

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Title: Design and synthesis of novel, potent and selective hypoxanthine analogs as adenosine A1 receptor antagonists and their biological evaluation.
Authors: Koul S; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India. Electronic address: summon.koul@advinus.com., Ramdas V; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Barawkar DA; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Waman YB; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Prasad N; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Madadi SK; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Shejul YD; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Bonagiri R; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Basu S; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Menon S; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Reddy SB; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Chaturvedi S; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Chennamaneni SR; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Bedse G; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Thakare R; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Gundu J; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Chaudhary S; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., De S; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Meru AV; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Palle V; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Chugh A; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India., Mookhtiar KA; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2017 Mar 15; Vol. 25 (6), pp. 1963-1975. Date of Electronic Publication: 2017 Feb 16.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: Design and synthesis of novel, potent and selective hypoxanthine analogs as adenosine A<subscript>1</subscript> receptor antagonists and their biological evaluation.
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  Data: <searchLink fieldCode="AU" term="%22Koul+S%22">Koul S</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India. Electronic address: summon.koul@advinus.com.<br /><searchLink fieldCode="AU" term="%22Ramdas+V%22">Ramdas V</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22Barawkar+DA%22">Barawkar DA</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22Waman+YB%22">Waman YB</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22Prasad+N%22">Prasad N</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22Madadi+SK%22">Madadi SK</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22Shejul+YD%22">Shejul YD</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22Bonagiri+R%22">Bonagiri R</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22Basu+S%22">Basu S</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22Menon+S%22">Menon S</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22Reddy+SB%22">Reddy SB</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22Chaturvedi+S%22">Chaturvedi S</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22Chennamaneni+SR%22">Chennamaneni SR</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22Bedse+G%22">Bedse G</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22Thakare+R%22">Thakare R</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22Gundu+J%22">Gundu J</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22Chaudhary+S%22">Chaudhary S</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22De+S%22">De S</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22Meru+AV%22">Meru AV</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22Palle+V%22">Palle V</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22Chugh+A%22">Chugh A</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.<br /><searchLink fieldCode="AU" term="%22Mookhtiar+KA%22">Mookhtiar KA</searchLink>; Drug Discovery Unit, Advinus Therapeutics Ltd., Hinjewadi, Pune 411 057, India.
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  Data: <searchLink fieldCode="JN" term="%229413298%22">Bioorganic & medicinal chemistry</searchLink> [Bioorg Med Chem] 2017 Mar 15; Vol. 25 (6), pp. 1963-1975. <i>Date of Electronic Publication: </i>2017 Feb 16.
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        Value: 10.1016/j.bmc.2017.02.029
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