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Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).

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Title: Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).
Authors: Gopalsamy A; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Narayanan A; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Liu S; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Parikh MD; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Kyne RE Jr; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Fadeyi O; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Tones MA; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Cherry JJ; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Nabhan JF; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., LaRosa G; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Petersen DN; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Menard C; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Foley TL; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Noell S; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Ren Y; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Loria PM; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Maglich-Goodwin J; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Rong H; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Jones LH; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2017 Apr 13; Vol. 60 (7), pp. 3094-3108. Date of Electronic Publication: 2017 Mar 16.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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DbLabel: MEDLINE Ultimate
An: 28257199
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PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).
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  Data: <searchLink fieldCode="AU" term="%22Gopalsamy+A%22">Gopalsamy A</searchLink>; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Narayanan+A%22">Narayanan A</searchLink>; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Liu+S%22">Liu S</searchLink>; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Parikh+MD%22">Parikh MD</searchLink>; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Kyne+RE+Jr%22">Kyne RE Jr</searchLink>; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Fadeyi+O%22">Fadeyi O</searchLink>; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Tones+MA%22">Tones MA</searchLink>; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Cherry+JJ%22">Cherry JJ</searchLink>; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Nabhan+JF%22">Nabhan JF</searchLink>; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22LaRosa+G%22">LaRosa G</searchLink>; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Petersen+DN%22">Petersen DN</searchLink>; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Menard+C%22">Menard C</searchLink>; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Foley+TL%22">Foley TL</searchLink>; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Noell+S%22">Noell S</searchLink>; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Ren+Y%22">Ren Y</searchLink>; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Loria+PM%22">Loria PM</searchLink>; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Maglich-Goodwin+J%22">Maglich-Goodwin J</searchLink>; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Rong+H%22">Rong H</searchLink>; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.<br /><searchLink fieldCode="AU" term="%22Jones+LH%22">Jones LH</searchLink>; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2017 Apr 13; Vol. 60 (7), pp. 3094-3108. <i>Date of Electronic Publication: </i>2017 Mar 16.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.jmedchem.7b00124
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        Text: English
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      – TitleFull: Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).
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