Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).
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| Title: | Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA). |
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| Authors: | Gopalsamy A; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Narayanan A; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Liu S; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Parikh MD; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Kyne RE Jr; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Fadeyi O; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Tones MA; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Cherry JJ; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Nabhan JF; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., LaRosa G; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Petersen DN; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Menard C; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Foley TL; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Noell S; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Ren Y; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Loria PM; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Maglich-Goodwin J; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Rong H; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States., Jones LH; Medicine Design and ‡Rare Disease Research Unit, #Pharmacokinetics and Drug Metabolism, Pfizer , 610 Main Street, Cambridge, Massachusetts 02139, United States.; Medicine Design and †Primary Pharmacology Group, Pfizer , Eastern Point Road, Groton, Connecticut 06340, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2017 Apr 13; Vol. 60 (7), pp. 3094-3108. Date of Electronic Publication: 2017 Mar 16. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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