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Localization and in-Vivo Characterization of Thapsia garganica CYP76AE2 Indicates a Role in Thapsigargin Biosynthesis.

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Title: Localization and in-Vivo Characterization of Thapsia garganica CYP76AE2 Indicates a Role in Thapsigargin Biosynthesis.
Authors: Andersen TB; Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark (T.B.A., K.J., J.A.-R.).; Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark (K.A.M.).; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, 2800 Kgs. Lyngby, Denmark (K.A.M., S.A.R., H.T.S.).; Metabolomics Australia, School of BioSciences, University of Melbourne, Melbourne, Victoria 3010, Australia (B.A.B.); and.; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark (N.N., S.B.C.)., Martinez-Swatson KA; Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark (T.B.A., K.J., J.A.-R.).; Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark (K.A.M.).; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, 2800 Kgs. Lyngby, Denmark (K.A.M., S.A.R., H.T.S.).; Metabolomics Australia, School of BioSciences, University of Melbourne, Melbourne, Victoria 3010, Australia (B.A.B.); and.; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark (N.N., S.B.C.)., Rasmussen SA; Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark (T.B.A., K.J., J.A.-R.).; Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark (K.A.M.).; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, 2800 Kgs. Lyngby, Denmark (K.A.M., S.A.R., H.T.S.).; Metabolomics Australia, School of BioSciences, University of Melbourne, Melbourne, Victoria 3010, Australia (B.A.B.); and.; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark (N.N., S.B.C.)., Boughton BA; Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark (T.B.A., K.J., J.A.-R.).; Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark (K.A.M.).; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, 2800 Kgs. Lyngby, Denmark (K.A.M., S.A.R., H.T.S.).; Metabolomics Australia, School of BioSciences, University of Melbourne, Melbourne, Victoria 3010, Australia (B.A.B.); and.; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark (N.N., S.B.C.)., Jørgensen K; Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark (T.B.A., K.J., J.A.-R.).; Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark (K.A.M.).; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, 2800 Kgs. Lyngby, Denmark (K.A.M., S.A.R., H.T.S.).; Metabolomics Australia, School of BioSciences, University of Melbourne, Melbourne, Victoria 3010, Australia (B.A.B.); and.; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark (N.N., S.B.C.)., Andersen-Ranberg J; Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark (T.B.A., K.J., J.A.-R.).; Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark (K.A.M.).; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, 2800 Kgs. Lyngby, Denmark (K.A.M., S.A.R., H.T.S.).; Metabolomics Australia, School of BioSciences, University of Melbourne, Melbourne, Victoria 3010, Australia (B.A.B.); and.; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark (N.N., S.B.C.)., Nyberg N; Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark (T.B.A., K.J., J.A.-R.).; Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark (K.A.M.).; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, 2800 Kgs. Lyngby, Denmark (K.A.M., S.A.R., H.T.S.).; Metabolomics Australia, School of BioSciences, University of Melbourne, Melbourne, Victoria 3010, Australia (B.A.B.); and.; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark (N.N., S.B.C.)., Christensen SB; Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark (T.B.A., K.J., J.A.-R.).; Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark (K.A.M.).; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, 2800 Kgs. Lyngby, Denmark (K.A.M., S.A.R., H.T.S.).; Metabolomics Australia, School of BioSciences, University of Melbourne, Melbourne, Victoria 3010, Australia (B.A.B.); and.; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark (N.N., S.B.C.)., Simonsen HT; Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark (T.B.A., K.J., J.A.-R.); hets@dtu.dk.; Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark (K.A.M.); hets@dtu.dk.; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, 2800 Kgs. Lyngby, Denmark (K.A.M., S.A.R., H.T.S.); hets@dtu.dk.; Metabolomics Australia, School of BioSciences, University of Melbourne, Melbourne, Victoria 3010, Australia (B.A.B.); and hets@dtu.dk.; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark (N.N., S.B.C.) hets@dtu.dk.
Source: Plant physiology [Plant Physiol] 2017 May; Vol. 174 (1), pp. 56-72. Date of Electronic Publication: 2017 Mar 08.
Publication Type: Journal Article
Journal Info: Publisher: American Society of Plant Biologists Country of Publication: United States NLM ID: 0401224 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-2548 (Electronic) Linking ISSN: 00320889 NLM ISO Abbreviation: Plant Physiol Subsets: MEDLINE
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  Data: Localization and in-Vivo Characterization of Thapsia garganica CYP76AE2 Indicates a Role in Thapsigargin Biosynthesis.
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  Data: <searchLink fieldCode="AU" term="%22Andersen+TB%22">Andersen TB</searchLink>; Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark (T.B.A., K.J., J.A.-R.).; Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark (K.A.M.).; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, 2800 Kgs. Lyngby, Denmark (K.A.M., S.A.R., H.T.S.).; Metabolomics Australia, School of BioSciences, University of Melbourne, Melbourne, Victoria 3010, Australia (B.A.B.); and.; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark (N.N., S.B.C.).<br /><searchLink fieldCode="AU" term="%22Martinez-Swatson+KA%22">Martinez-Swatson KA</searchLink>; Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark (T.B.A., K.J., J.A.-R.).; Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark (K.A.M.).; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, 2800 Kgs. Lyngby, Denmark (K.A.M., S.A.R., H.T.S.).; Metabolomics Australia, School of BioSciences, University of Melbourne, Melbourne, Victoria 3010, Australia (B.A.B.); and.; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark (N.N., S.B.C.).<br /><searchLink fieldCode="AU" term="%22Rasmussen+SA%22">Rasmussen SA</searchLink>; Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark (T.B.A., K.J., J.A.-R.).; Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark (K.A.M.).; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, 2800 Kgs. 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Lyngby, Denmark (K.A.M., S.A.R., H.T.S.).; Metabolomics Australia, School of BioSciences, University of Melbourne, Melbourne, Victoria 3010, Australia (B.A.B.); and.; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark (N.N., S.B.C.).<br /><searchLink fieldCode="AU" term="%22Jørgensen+K%22">Jørgensen K</searchLink>; Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark (T.B.A., K.J., J.A.-R.).; Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark (K.A.M.).; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, 2800 Kgs. Lyngby, Denmark (K.A.M., S.A.R., H.T.S.).; Metabolomics Australia, School of BioSciences, University of Melbourne, Melbourne, Victoria 3010, Australia (B.A.B.); and.; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark (N.N., S.B.C.).<br /><searchLink fieldCode="AU" term="%22Andersen-Ranberg+J%22">Andersen-Ranberg J</searchLink>; Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark (T.B.A., K.J., J.A.-R.).; Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark (K.A.M.).; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, 2800 Kgs. Lyngby, Denmark (K.A.M., S.A.R., H.T.S.).; Metabolomics Australia, School of BioSciences, University of Melbourne, Melbourne, Victoria 3010, Australia (B.A.B.); and.; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark (N.N., S.B.C.).<br /><searchLink fieldCode="AU" term="%22Nyberg+N%22">Nyberg N</searchLink>; Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark (T.B.A., K.J., J.A.-R.).; Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark (K.A.M.).; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, 2800 Kgs. Lyngby, Denmark (K.A.M., S.A.R., H.T.S.).; Metabolomics Australia, School of BioSciences, University of Melbourne, Melbourne, Victoria 3010, Australia (B.A.B.); and.; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark (N.N., S.B.C.).<br /><searchLink fieldCode="AU" term="%22Christensen+SB%22">Christensen SB</searchLink>; Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark (T.B.A., K.J., J.A.-R.).; Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark (K.A.M.).; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, 2800 Kgs. Lyngby, Denmark (K.A.M., S.A.R., H.T.S.).; Metabolomics Australia, School of BioSciences, University of Melbourne, Melbourne, Victoria 3010, Australia (B.A.B.); and.; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark (N.N., S.B.C.).<br /><searchLink fieldCode="AU" term="%22Simonsen+HT%22">Simonsen HT</searchLink>; Department of Plant and Environmental Sciences, University of Copenhagen, 1871 Frederiksberg C, Denmark (T.B.A., K.J., J.A.-R.); hets@dtu.dk.; Natural History Museum of Denmark, University of Copenhagen, DK-1350 Copenhagen K, Denmark (K.A.M.); hets@dtu.dk.; Department of Biotechnology and Biomedicine, Technical University of Denmark, Søltofts Plads, 2800 Kgs. Lyngby, Denmark (K.A.M., S.A.R., H.T.S.); hets@dtu.dk.; Metabolomics Australia, School of BioSciences, University of Melbourne, Melbourne, Victoria 3010, Australia (B.A.B.); and hets@dtu.dk.; Department of Drug Design and Pharmacology, University of Copenhagen, 2100 Copenhagen, Denmark (N.N., S.B.C.) hets@dtu.dk.
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