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Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.

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Title: Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.
Authors: Blevitt JM; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC , La Jolla, California 92121, United States., Hack MD; Lead Discovery, Discovery Sciences, Janssen R&D LLC , La Jolla, California 92121, United States., Herman KL; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC , La Jolla, California 92121, United States., Jackson PF; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC , La Jolla, California 92121, United States., Krawczuk PJ; Immunology, Janssen R&D LLC , Spring House, Pennsylvania 19477, United States., Lebsack AD; Immunology, Janssen R&D LLC , La Jolla, California 92121, United States., Liu AX; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC , Spring House, Pennsylvania 19477, United States., Mirzadegan T; Lead Discovery, Discovery Sciences, Janssen R&D LLC , La Jolla, California 92121, United States., Nelen MI; Lead Discovery, Discovery Sciences, Janssen R&D LLC , Spring House, Pennsylvania 19477, United States., Patrick AN; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC , Spring House, Pennsylvania 19477, United States., Steinbacher S; Proteros Biostructures , 82152 Martinsried, Germany., Milla ME; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC , La Jolla, California 92121, United States., Lumb KJ; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC , Spring House, Pennsylvania 19477, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2017 Apr 27; Vol. 60 (8), pp. 3511-3517. Date of Electronic Publication: 2017 Mar 16.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction.
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  Data: <searchLink fieldCode="AU" term="%22Blevitt+JM%22">Blevitt JM</searchLink>; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC , La Jolla, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Hack+MD%22">Hack MD</searchLink>; Lead Discovery, Discovery Sciences, Janssen R&D LLC , La Jolla, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Herman+KL%22">Herman KL</searchLink>; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC , La Jolla, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Jackson+PF%22">Jackson PF</searchLink>; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC , La Jolla, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Krawczuk+PJ%22">Krawczuk PJ</searchLink>; Immunology, Janssen R&D LLC , Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Lebsack+AD%22">Lebsack AD</searchLink>; Immunology, Janssen R&D LLC , La Jolla, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Liu+AX%22">Liu AX</searchLink>; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC , Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Mirzadegan+T%22">Mirzadegan T</searchLink>; Lead Discovery, Discovery Sciences, Janssen R&D LLC , La Jolla, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Nelen+MI%22">Nelen MI</searchLink>; Lead Discovery, Discovery Sciences, Janssen R&D LLC , Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Patrick+AN%22">Patrick AN</searchLink>; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC , Spring House, Pennsylvania 19477, United States.<br /><searchLink fieldCode="AU" term="%22Steinbacher+S%22">Steinbacher S</searchLink>; Proteros Biostructures , 82152 Martinsried, Germany.<br /><searchLink fieldCode="AU" term="%22Milla+ME%22">Milla ME</searchLink>; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC , La Jolla, California 92121, United States.<br /><searchLink fieldCode="AU" term="%22Lumb+KJ%22">Lumb KJ</searchLink>; Emerging Science & Innovation, Discovery Sciences, Janssen R&D LLC , Spring House, Pennsylvania 19477, United States.
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2017 Apr 27; Vol. 60 (8), pp. 3511-3517. <i>Date of Electronic Publication: </i>2017 Mar 16.
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