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Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.

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Title: Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.
Authors: Mandal M; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Tan Z; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Madsen-Duggan C; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Buevich AV; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Caldwell JP; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Dejesus R; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Flattery A; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Garlisi CG; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Gill C; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Ha SN; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Ho G; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Koseoglu S; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Labroli M; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Basu K; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Lee SH; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Liang L; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Liu J; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Mayhood T; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., McGuinness D; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., McLaren DG; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Wen X; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Parmee E; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Rindgen D; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Roemer T; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Sheth P; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Tawa P; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Tata J; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Yang C; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Yang SW; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Xiao L; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Wang H; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Tan C; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Tang H; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Walsh P; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Walsh E; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Wu J; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States., Su J; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.
Source: Journal of medicinal chemistry [J Med Chem] 2017 May 11; Vol. 60 (9), pp. 3851-3865. Date of Electronic Publication: 2017 Mar 29.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Mandal+M%22">Mandal M</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Tan+Z%22">Tan Z</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Madsen-Duggan+C%22">Madsen-Duggan C</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Buevich+AV%22">Buevich AV</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Caldwell+JP%22">Caldwell JP</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Dejesus+R%22">Dejesus R</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Flattery+A%22">Flattery A</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Garlisi+CG%22">Garlisi CG</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Gill+C%22">Gill C</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Ha+SN%22">Ha SN</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Ho+G%22">Ho G</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Koseoglu+S%22">Koseoglu S</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Labroli+M%22">Labroli M</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Basu+K%22">Basu K</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Lee+SH%22">Lee SH</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Liang+L%22">Liang L</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Liu+J%22">Liu J</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Mayhood+T%22">Mayhood T</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22McGuinness+D%22">McGuinness D</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22McLaren+DG%22">McLaren DG</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Wen+X%22">Wen X</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Parmee+E%22">Parmee E</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Rindgen+D%22">Rindgen D</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Roemer+T%22">Roemer T</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Sheth+P%22">Sheth P</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Tawa+P%22">Tawa P</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Tata+J%22">Tata J</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Yang+C%22">Yang C</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Yang+SW%22">Yang SW</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Xiao+L%22">Xiao L</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Tan+C%22">Tan C</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Tang+H%22">Tang H</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Walsh+P%22">Walsh P</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Walsh+E%22">Walsh E</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Wu+J%22">Wu J</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.<br /><searchLink fieldCode="AU" term="%22Su+J%22">Su J</searchLink>; Global Chemistry, ‡Early Discovery Bacteriology, §Discovery Pharmaceutical Sciences, ∥Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, ⊥In Vivo Pharmacology, and #In Vitro Pharmacology, MRL, Merck & Co., Inc. , Kenilworth, New Jersey 07033, United States.
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      – PersonEntity:
          Name:
            NameFull: Lee SH
      – PersonEntity:
          Name:
            NameFull: Liang L
      – PersonEntity:
          Name:
            NameFull: Liu J
      – PersonEntity:
          Name:
            NameFull: Mayhood T
      – PersonEntity:
          Name:
            NameFull: McGuinness D
      – PersonEntity:
          Name:
            NameFull: McLaren DG
      – PersonEntity:
          Name:
            NameFull: Wen X
      – PersonEntity:
          Name:
            NameFull: Parmee E
      – PersonEntity:
          Name:
            NameFull: Rindgen D
      – PersonEntity:
          Name:
            NameFull: Roemer T
      – PersonEntity:
          Name:
            NameFull: Sheth P
      – PersonEntity:
          Name:
            NameFull: Tawa P
      – PersonEntity:
          Name:
            NameFull: Tata J
      – PersonEntity:
          Name:
            NameFull: Yang C
      – PersonEntity:
          Name:
            NameFull: Yang SW
      – PersonEntity:
          Name:
            NameFull: Xiao L
      – PersonEntity:
          Name:
            NameFull: Wang H
      – PersonEntity:
          Name:
            NameFull: Tan C
      – PersonEntity:
          Name:
            NameFull: Tang H
      – PersonEntity:
          Name:
            NameFull: Walsh P
      – PersonEntity:
          Name:
            NameFull: Walsh E
      – PersonEntity:
          Name:
            NameFull: Wu J
      – PersonEntity:
          Name:
            NameFull: Su J
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 11
              M: 05
              Text: 2017 May 11
              Type: published
              Y: 2017
          Identifiers:
            – Type: issn-electronic
              Value: 1520-4804
          Numbering:
            – Type: volume
              Value: 60
            – Type: issue
              Value: 9
          Titles:
            – TitleFull: Journal of medicinal chemistry
              Type: main
ResultId 1