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Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.

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Title: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.
Authors: Lintner NG; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America., McClure KF; Pfizer Medicinal Chemistry, Cardiovascular, Metabolic and Endocrine Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America., Petersen D; Primary Pharmacology Group, Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America., Londregan AT; Pfizer Medicinal Chemistry, Cardiovascular, Metabolic and Endocrine Disease Research Unit, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America., Piotrowski DW; Pfizer Medicinal Chemistry, Cardiovascular, Metabolic and Endocrine Disease Research Unit, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America., Wei L; Pfizer Medicinal Chemistry, Cardiovascular, Metabolic and Endocrine Disease Research Unit, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America., Xiao J; Pfizer Medicinal Chemistry, Cardiovascular, Metabolic and Endocrine Disease Research Unit, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America., Bolt M; Drug Safety Research & Development, Pfizer Worldwide Research & Development, Andover, Massachusetts, United States of America., Loria PM; Primary Pharmacology Group, Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America., Maguire B; Primary Pharmacology Group, Pharmacokinetics, Dynamics and Metabolism, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America., Geoghegan KF; Pfizer Medicinal Chemistry, Structural Biology and Biophysics, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America., Huang A; Pfizer Medicinal Chemistry, Computational Sciences, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America., Rolph T; Cardiovascular, Metabolic and Endocrine Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America., Liras S; Pfizer Medicinal Chemistry, Cardiovascular, Metabolic and Endocrine Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America.; Pfizer Medicinal Chemistry, Cardiovascular, Metabolic and Endocrine Disease Research Unit, Pfizer Worldwide Research and Development, Groton, Connecticut, United States of America., Doudna JA; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America.; QB3 Institute, University of California, Berkeley, Berkeley, California, United States of America.; Department of Chemistry, University of California, Berkeley, Berkeley, California, United States of America.; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America.; Howard Hughes Medical Institute (HHMI), University of California, Berkeley, Berkeley, California, United States of America., Dullea RG; Cardiovascular, Metabolic and Endocrine Disease Research Unit, Pfizer Worldwide Research and Development, Cambridge, Massachusetts, United States of America., Cate JH; Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America.; QB3 Institute, University of California, Berkeley, Berkeley, California, United States of America.; Department of Chemistry, University of California, Berkeley, Berkeley, California, United States of America.; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, California, United States of America.
Source: PLoS biology [PLoS Biol] 2017 Mar 21; Vol. 15 (3), pp. e2001882. Date of Electronic Publication: 2017 Mar 21 (Print Publication: 2017).
Publication Type: Journal Article; Validation Study
Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE
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