A spontaneous mutation in kdsD, a biosynthesis gene for 3 Deoxy-D-manno-Octulosonic Acid, occurred in a ciprofloxacin resistant strain of Francisella tularensis and caused a high level of attenuation in murine models of tularemia. - Chance T; Chua J; Toothman RG; Ladner JT; Nuss JE; Raymond JL; Biot FV; Demons S; Miller L; Halasohoris S; Mou S; Koroleva G; et al. (PloS one, 2017)