A spontaneous mutation in kdsD, a biosynthesis gene for 3 Deoxy-D-manno-Octulosonic Acid, occurred in a ciprofloxacin resistant strain of Francisella tularensis and caused a high level of attenuation in murine models of tularemia.

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Title:	A spontaneous mutation in kdsD, a biosynthesis gene for 3 Deoxy-D-manno-Octulosonic Acid, occurred in a ciprofloxacin resistant strain of Francisella tularensis and caused a high level of attenuation in murine models of tularemia.
Authors:	Chance T; Pathology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, MD, United States of America., Chua J; Bacteriology Division, USAMRIID, Fort Detrick, Frederick, MD, United States of America., Toothman RG; Bacteriology Division, USAMRIID, Fort Detrick, Frederick, MD, United States of America., Ladner JT; Center for Genome Sciences, USAMRIID, Fort Detrick, Frederick, MD, United States of America., Nuss JE; Department of Molecular and Translational Sciences, USAMRIID, Fort Detrick, Frederick, MD, United States of America., Raymond JL; Pathology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Fort Detrick, Frederick, MD, United States of America., Biot FV; Institut de Recherche Biomédicale des Armées, Département de Biologie des Agents Transmissibles, Unité de Bactériologie/UMR_MD1, B.P. 73, Brétigny-sur-Orge, France., Demons S; Bacteriology Division, USAMRIID, Fort Detrick, Frederick, MD, United States of America., Miller L; Bacteriology Division, USAMRIID, Fort Detrick, Frederick, MD, United States of America., Halasohoris S; Bacteriology Division, USAMRIID, Fort Detrick, Frederick, MD, United States of America., Mou S; Bacteriology Division, USAMRIID, Fort Detrick, Frederick, MD, United States of America., Koroleva G; Center for Genome Sciences, USAMRIID, Fort Detrick, Frederick, MD, United States of America., Lovett S; Center for Genome Sciences, USAMRIID, Fort Detrick, Frederick, MD, United States of America., Palacios G; Center for Genome Sciences, USAMRIID, Fort Detrick, Frederick, MD, United States of America., Vietri NJ; Bacteriology Division, USAMRIID, Fort Detrick, Frederick, MD, United States of America., Worsham PL; Bacteriology Division, USAMRIID, Fort Detrick, Frederick, MD, United States of America., Cote CK; Bacteriology Division, USAMRIID, Fort Detrick, Frederick, MD, United States of America., Kijek TM; Department of Molecular and Translational Sciences, USAMRIID, Fort Detrick, Frederick, MD, United States of America., Bozue JA; Bacteriology Division, USAMRIID, Fort Detrick, Frederick, MD, United States of America.
Source:	PloS one [PLoS One] 2017 Mar 22; Vol. 12 (3), pp. e0174106. Date of Electronic Publication: 2017 Mar 22 (Print Publication: 2017).
Publication Type:	Journal Article
Journal Info:	Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
Database:	MEDLINE Ultimate

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ISSN:	1932-6203
DOI:	10.1371/journal.pone.0174106