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Rafoxanide and Closantel Inhibit SPAK and OSR1 Kinases by Binding to a Highly Conserved Allosteric Site on Their C-terminal Domains.

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Title: Rafoxanide and Closantel Inhibit SPAK and OSR1 Kinases by Binding to a Highly Conserved Allosteric Site on Their C-terminal Domains.
Authors: AlAmri MA; School of Pharmacy, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Kadri H; School of Pharmacy, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Alderwick LJ; Birmingham Drug Discovery Facility, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Simpkins NS; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK., Mehellou Y; School of Pharmacy and Pharmaceutical Sciences, Redwood Building, Cardiff University, Cardiff, CF10 3NB, UK.
Source: ChemMedChem [ChemMedChem] 2017 May 09; Vol. 12 (9), pp. 639-645. Date of Electronic Publication: 2017 Apr 12.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22AlAmri+MA%22">AlAmri MA</searchLink>; School of Pharmacy, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.<br /><searchLink fieldCode="AU" term="%22Kadri+H%22">Kadri H</searchLink>; School of Pharmacy, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.<br /><searchLink fieldCode="AU" term="%22Alderwick+LJ%22">Alderwick LJ</searchLink>; Birmingham Drug Discovery Facility, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.<br /><searchLink fieldCode="AU" term="%22Simpkins+NS%22">Simpkins NS</searchLink>; School of Chemistry, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.<br /><searchLink fieldCode="AU" term="%22Mehellou+Y%22">Mehellou Y</searchLink>; School of Pharmacy and Pharmaceutical Sciences, Redwood Building, Cardiff University, Cardiff, CF10 3NB, UK.
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