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Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2.

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Title: Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2.
Authors: Casás-Selves M; Oncology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.; Present address: Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, ON, M5G 0A3, Canada., Zhang AX; Discovery Sciences-Chemical Biology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA., Dowling JE; Oncology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA., Hallén S; Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Discovery Unit, AstraZeneca, Pepparedsleden 1, Mölndal, 431 83, Sweden., Kawatkar A; Discovery Sciences-Chemical Biology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA., Pace NJ; Department of Chemistry, Boston College, Chestnut Hill, MA, 02467, USA., Denz CR; Oncology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA., Pontz T; Oncology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA., Garahdaghi F; Oncology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.; Present address: Synageva BioPharma Corp., 33 Hayden Avenue, Lexington, MA, 02421, USA., Cao Q; Discovery Sciences-Computational Chemistry, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.; Present address: Ra Pharmaceuticals, Inc., 87 Cambridge Park Drive, Cambridge, MA, 02140, USA., Sabirsh A; Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Discovery Unit, AstraZeneca, Pepparedsleden 1, Mölndal, 431 83, Sweden., Thakur K; Oncology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA., O'Connell N; Discovery Sciences-Structure and Biophysics, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.; Present address: Nurix, Inc., 1700 Owens Street, Suite 290, San Francisco, CA, 94158, USA., Hu J; Discovery Sciences-Structure and Biophysics, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.; Present address: Shire, 300 Shire Way, Lexington, MA, 02421, USA., Cornella-Taracido I; Discovery Sciences-Chemical Biology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.; Present address: Discovery Chemistry, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA., Weerapana E; Department of Chemistry, Boston College, Chestnut Hill, MA, 02467, USA., Zinda M; Oncology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA., Goodnow RA Jr; Discovery Sciences-Chemical Biology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.; Present address: Pharmaron, 303 Wyman Street, Room 322, Waltham, MA, 02451, USA., Castaldi MP; Discovery Sciences-Chemical Biology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.
Source: ChemMedChem [ChemMedChem] 2017 Jun 21; Vol. 12 (12), pp. 917-924. Date of Electronic Publication: 2017 Apr 26.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE
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  Data: Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2.
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  Data: <searchLink fieldCode="AU" term="%22Casás-Selves+M%22">Casás-Selves M</searchLink>; Oncology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.; Present address: Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, ON, M5G 0A3, Canada.<br /><searchLink fieldCode="AU" term="%22Zhang+AX%22">Zhang AX</searchLink>; Discovery Sciences-Chemical Biology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.<br /><searchLink fieldCode="AU" term="%22Dowling+JE%22">Dowling JE</searchLink>; Oncology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.<br /><searchLink fieldCode="AU" term="%22Hallén+S%22">Hallén S</searchLink>; Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Discovery Unit, AstraZeneca, Pepparedsleden 1, Mölndal, 431 83, Sweden.<br /><searchLink fieldCode="AU" term="%22Kawatkar+A%22">Kawatkar A</searchLink>; Discovery Sciences-Chemical Biology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.<br /><searchLink fieldCode="AU" term="%22Pace+NJ%22">Pace NJ</searchLink>; Department of Chemistry, Boston College, Chestnut Hill, MA, 02467, USA.<br /><searchLink fieldCode="AU" term="%22Denz+CR%22">Denz CR</searchLink>; Oncology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.<br /><searchLink fieldCode="AU" term="%22Pontz+T%22">Pontz T</searchLink>; Oncology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.<br /><searchLink fieldCode="AU" term="%22Garahdaghi+F%22">Garahdaghi F</searchLink>; Oncology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.; Present address: Synageva BioPharma Corp., 33 Hayden Avenue, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Cao+Q%22">Cao Q</searchLink>; Discovery Sciences-Computational Chemistry, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.; Present address: Ra Pharmaceuticals, Inc., 87 Cambridge Park Drive, Cambridge, MA, 02140, USA.<br /><searchLink fieldCode="AU" term="%22Sabirsh+A%22">Sabirsh A</searchLink>; Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Discovery Unit, AstraZeneca, Pepparedsleden 1, Mölndal, 431 83, Sweden.<br /><searchLink fieldCode="AU" term="%22Thakur+K%22">Thakur K</searchLink>; Oncology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.<br /><searchLink fieldCode="AU" term="%22O'Connell+N%22">O'Connell N</searchLink>; Discovery Sciences-Structure and Biophysics, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.; Present address: Nurix, Inc., 1700 Owens Street, Suite 290, San Francisco, CA, 94158, USA.<br /><searchLink fieldCode="AU" term="%22Hu+J%22">Hu J</searchLink>; Discovery Sciences-Structure and Biophysics, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.; Present address: Shire, 300 Shire Way, Lexington, MA, 02421, USA.<br /><searchLink fieldCode="AU" term="%22Cornella-Taracido+I%22">Cornella-Taracido I</searchLink>; Discovery Sciences-Chemical Biology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.; Present address: Discovery Chemistry, Merck Research Laboratories, 33 Avenue Louis Pasteur, Boston, MA, 02115, USA.<br /><searchLink fieldCode="AU" term="%22Weerapana+E%22">Weerapana E</searchLink>; Department of Chemistry, Boston College, Chestnut Hill, MA, 02467, USA.<br /><searchLink fieldCode="AU" term="%22Zinda+M%22">Zinda M</searchLink>; Oncology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.<br /><searchLink fieldCode="AU" term="%22Goodnow+RA+Jr%22">Goodnow RA Jr</searchLink>; Discovery Sciences-Chemical Biology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.; Present address: Pharmaron, 303 Wyman Street, Room 322, Waltham, MA, 02451, USA.<br /><searchLink fieldCode="AU" term="%22Castaldi+MP%22">Castaldi MP</searchLink>; Discovery Sciences-Chemical Biology, Innovative Medicines and Early Discovery Unit, AstraZeneca, 35 Gatehouse Drive, Waltham, MA, 02451, USA.
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  Data: <searchLink fieldCode="JN" term="%22101259013%22">ChemMedChem</searchLink> [ChemMedChem] 2017 Jun 21; Vol. 12 (12), pp. 917-924. <i>Date of Electronic Publication: </i>2017 Apr 26.
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