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Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates.

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Title: Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates.
Authors: Sun X; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Ponte JF; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Yoder NC; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Laleau R; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Coccia J; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Lanieri L; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Qiu Q; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Wu R; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Hong E; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Bogalhas M; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Wang L; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Dong L; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Setiady Y; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Maloney EK; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Ab O; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Zhang X; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Pinkas J; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Keating TA; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Chari R; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Erickson HK; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States., Lambert JM; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.
Source: Bioconjugate chemistry [Bioconjug Chem] 2017 May 17; Vol. 28 (5), pp. 1371-1381. Date of Electronic Publication: 2017 Apr 13.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9010319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4812 (Electronic) Linking ISSN: 10431802 NLM ISO Abbreviation: Bioconjug Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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  Data: Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates.
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  Data: <searchLink fieldCode="AU" term="%22Sun+X%22">Sun X</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Ponte+JF%22">Ponte JF</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Yoder+NC%22">Yoder NC</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Laleau+R%22">Laleau R</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Coccia+J%22">Coccia J</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Lanieri+L%22">Lanieri L</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Qiu+Q%22">Qiu Q</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Wu+R%22">Wu R</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Hong+E%22">Hong E</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Bogalhas+M%22">Bogalhas M</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Wang+L%22">Wang L</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Dong+L%22">Dong L</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Setiady+Y%22">Setiady Y</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Maloney+EK%22">Maloney EK</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Ab+O%22">Ab O</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Pinkas+J%22">Pinkas J</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Keating+TA%22">Keating TA</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Chari+R%22">Chari R</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Erickson+HK%22">Erickson HK</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.<br /><searchLink fieldCode="AU" term="%22Lambert+JM%22">Lambert JM</searchLink>; ImmunoGen, Inc. , 830 Winter Street, Waltham, Massachusetts 02451, United States.
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  Data: <searchLink fieldCode="JN" term="%229010319%22">Bioconjugate chemistry</searchLink> [Bioconjug Chem] 2017 May 17; Vol. 28 (5), pp. 1371-1381. <i>Date of Electronic Publication: </i>2017 Apr 13.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9010319 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4812 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210431802%22">10431802 </searchLink><i>NLM ISO Abbreviation: </i>Bioconjug Chem <i>Subsets: </i>MEDLINE
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        Value: 10.1021/acs.bioconjchem.7b00062
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