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Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.

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Title: Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.
Authors: Hoyt SB; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States. Electronic address: scott.hoyt@alumni.upenn.edu., Taylor J; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., London C; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Ali A; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Ujjainwalla F; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Tata J; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Struthers M; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Cully D; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Wisniewski T; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Ren N; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Bopp C; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Sok A; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Verras A; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., McMasters D; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Chen Q; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Tung E; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Tang W; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Salituro G; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Clemas J; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Zhou G; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., MacNeil D; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Duffy R; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States., Xiong Y; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Jun 01; Vol. 27 (11), pp. 2384-2388. Date of Electronic Publication: 2017 Apr 08.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
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  Data: Discovery of indazole aldosterone synthase (CYP11B2) inhibitors as potential treatments for hypertension.
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  Data: <searchLink fieldCode="AU" term="%22Hoyt+SB%22">Hoyt SB</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States. Electronic address: scott.hoyt@alumni.upenn.edu.<br /><searchLink fieldCode="AU" term="%22Taylor+J%22">Taylor J</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22London+C%22">London C</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22Ali+A%22">Ali A</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22Ujjainwalla+F%22">Ujjainwalla F</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22Tata+J%22">Tata J</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22Struthers+M%22">Struthers M</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22Cully+D%22">Cully D</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22Wisniewski+T%22">Wisniewski T</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22Ren+N%22">Ren N</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22Bopp+C%22">Bopp C</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22Sok+A%22">Sok A</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22Verras+A%22">Verras A</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22McMasters+D%22">McMasters D</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22Chen+Q%22">Chen Q</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22Tung+E%22">Tung E</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22Tang+W%22">Tang W</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22Salituro+G%22">Salituro G</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22Clemas+J%22">Clemas J</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22Zhou+G%22">Zhou G</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22MacNeil+D%22">MacNeil D</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22Duffy+R%22">Duffy R</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.<br /><searchLink fieldCode="AU" term="%22Xiong+Y%22">Xiong Y</searchLink>; Merck Research Laboratories, PO Box 2000, NJ 07065, Rahway, United States.
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  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2017 Jun 01; Vol. 27 (11), pp. 2384-2388. <i>Date of Electronic Publication: </i>2017 Apr 08.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9107377 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3405 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220960894X%22">0960894X </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem Lett <i>Subsets: </i>MEDLINE
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