Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles.
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| Title: | Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles. |
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| Authors: | Sanders JM; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States., Beshore DC; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States., Culberson JC; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States., Fells JI; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States., Imbriglio JE; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States., Gunaydin H; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States., Haidle AM; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States., Labroli M; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States., Mattioni BE; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States., Sciammetta N; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States., Shipe WD; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States., Sheridan RP; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States., Suen LM; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States., Verras A; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States., Walji A; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States., Joshi EM; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States., Bueters T; Modeling & Informatics, ‡Discovery Chemistry, and §Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Merck & Co., Inc. , Kenilworth, New Jersey 07065, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2017 Aug 24; Vol. 60 (16), pp. 6771-6780. Date of Electronic Publication: 2017 May 05. |
| Publication Type: | Journal Article; Review |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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