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Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.

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Title: Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment.
Authors: Jeon OH; Translational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA., Kim C; Translational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, South Korea., Laberge RM; Buck Institute for Research on Aging, Novato, California, USA.; Unity Biotechnology, Inc., Brisbane, California, USA., Demaria M; Buck Institute for Research on Aging, Novato, California, USA.; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands., Rathod S; Translational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA., Vasserot AP; Unity Biotechnology, Inc., Brisbane, California, USA., Chung JW; Translational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA., Kim DH; Translational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA., Poon Y; Unity Biotechnology, Inc., Brisbane, California, USA., David N; Unity Biotechnology, Inc., Brisbane, California, USA., Baker DJ; Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA., van Deursen JM; Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA., Campisi J; Buck Institute for Research on Aging, Novato, California, USA.; Lawrence Berkeley National Laboratory, University of California, Berkeley, Berkley, California, USA., Elisseeff JH; Translational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
Source: Nature medicine [Nat Med] 2017 Jun; Vol. 23 (6), pp. 775-781. Date of Electronic Publication: 2017 Apr 24.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Jeon+OH%22">Jeon OH</searchLink>; Translational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Kim+C%22">Kim C</searchLink>; Translational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Chemistry, Ulsan National Institute of Science and Technology, Ulsan, South Korea.<br /><searchLink fieldCode="AU" term="%22Laberge+RM%22">Laberge RM</searchLink>; Buck Institute for Research on Aging, Novato, California, USA.; Unity Biotechnology, Inc., Brisbane, California, USA.<br /><searchLink fieldCode="AU" term="%22Demaria+M%22">Demaria M</searchLink>; Buck Institute for Research on Aging, Novato, California, USA.; European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.<br /><searchLink fieldCode="AU" term="%22Rathod+S%22">Rathod S</searchLink>; Translational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Vasserot+AP%22">Vasserot AP</searchLink>; Unity Biotechnology, Inc., Brisbane, California, USA.<br /><searchLink fieldCode="AU" term="%22Chung+JW%22">Chung JW</searchLink>; Translational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Kim+DH%22">Kim DH</searchLink>; Translational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.<br /><searchLink fieldCode="AU" term="%22Poon+Y%22">Poon Y</searchLink>; Unity Biotechnology, Inc., Brisbane, California, USA.<br /><searchLink fieldCode="AU" term="%22David+N%22">David N</searchLink>; Unity Biotechnology, Inc., Brisbane, California, USA.<br /><searchLink fieldCode="AU" term="%22Baker+DJ%22">Baker DJ</searchLink>; Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22van+Deursen+JM%22">van Deursen JM</searchLink>; Department of Pediatric and Adolescent Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.<br /><searchLink fieldCode="AU" term="%22Campisi+J%22">Campisi J</searchLink>; Buck Institute for Research on Aging, Novato, California, USA.; Lawrence Berkeley National Laboratory, University of California, Berkeley, Berkley, California, USA.<br /><searchLink fieldCode="AU" term="%22Elisseeff+JH%22">Elisseeff JH</searchLink>; Translational Tissue Engineering Center, Wilmer Eye Institute and the Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
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  Data: <searchLink fieldCode="JN" term="%229502015%22">Nature medicine</searchLink> [Nat Med] 2017 Jun; Vol. 23 (6), pp. 775-781. <i>Date of Electronic Publication: </i>2017 Apr 24.
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