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Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy.

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Title: Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy.
Authors: Kline CN; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California San Francisco (UCSF), San Francisco, California, USA., Joseph NM; Department of Pathology, UCSF, San Francisco, California, USA.; Clinical Cancer Genomics Laboratory, UCSF, San Francisco, California, USA., Grenert JP; Department of Pathology, UCSF, San Francisco, California, USA.; Clinical Cancer Genomics Laboratory, UCSF, San Francisco, California, USA., van Ziffle J; Department of Pathology, UCSF, San Francisco, California, USA.; Clinical Cancer Genomics Laboratory, UCSF, San Francisco, California, USA., Talevich E; Clinical Cancer Genomics Laboratory, UCSF, San Francisco, California, USA., Onodera C; Clinical Cancer Genomics Laboratory, UCSF, San Francisco, California, USA., Aboian M; Department of Radiology, UCSF, San Francisco, California, USA., Cha S; Department of Radiology, UCSF, San Francisco, California, USA.; Department of Neurological Surgery, UCSF, San Francisco, California, USA., Raleigh DR; Department of Radiation Oncology, UCSF, San Francisco, California, USA., Braunstein S; Department of Radiation Oncology, UCSF, San Francisco, California, USA., Torkildson J; Division of Pediatric Hematology/Oncology, UCSF Benioff Children's Hospital Oakland,Oakland, California, USA., Samuel D; Division of Pediatric Hematology/Oncology, Valley Children's Hospital, Madera, California, USA., Bloomer M; Department of Ophthalmology, UCSF, San Francisco, California, USA., Campomanes AGA; Department of Ophthalmology, UCSF, San Francisco, California, USA., Banerjee A; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California San Francisco (UCSF), San Francisco, California, USA.; Department of Neurological Surgery, UCSF, San Francisco, California, USA., Butowski N; Division of Neuro-Oncology, Department of Neurological Surgery, UCSF, San Francisco, California, USA., Raffel C; Department of Neurological Surgery, UCSF, San Francisco, California, USA., Tihan T; Department of Pathology, UCSF, San Francisco, California, USA., Bollen AW; Department of Pathology, UCSF, San Francisco, California, USA., Phillips JJ; Department of Pathology, UCSF, San Francisco, California, USA.; Department of Neurological Surgery, UCSF, San Francisco, California, USA., Korn WM; Divisions of Gastroenterology and Medical Oncology, Department of Medicine, UCSF, San Francisco, California, USA., Yeh I; Department of Pathology, UCSF, San Francisco, California, USA.; Clinical Cancer Genomics Laboratory, UCSF, San Francisco, California, USA., Bastian BC; Department of Pathology, UCSF, San Francisco, California, USA.; Clinical Cancer Genomics Laboratory, UCSF, San Francisco, California, USA., Gupta N; Department of Neurological Surgery, UCSF, San Francisco, California, USA., Mueller S; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California San Francisco (UCSF), San Francisco, California, USA.; Department of Neurological Surgery, UCSF, San Francisco, California, USA., Perry A; Department of Pathology, UCSF, San Francisco, California, USA.; Department of Neurological Surgery, UCSF, San Francisco, California, USA., Nicolaides T; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California San Francisco (UCSF), San Francisco, California, USA.; Department of Neurological Surgery, UCSF, San Francisco, California, USA., Solomon DA; Department of Pathology, UCSF, San Francisco, California, USA.; Clinical Cancer Genomics Laboratory, UCSF, San Francisco, California, USA.
Source: Neuro-oncology [Neuro Oncol] 2017 May 01; Vol. 19 (5), pp. 699-709.
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 100887420 Publication Model: Print Cited Medium: Internet ISSN: 1523-5866 (Electronic) Linking ISSN: 15228517 NLM ISO Abbreviation: Neuro Oncol Subsets: MEDLINE
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  Data: Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy.
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  Data: <searchLink fieldCode="AU" term="%22Kline+CN%22">Kline CN</searchLink>; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California San Francisco (UCSF), San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Joseph+NM%22">Joseph NM</searchLink>; Department of Pathology, UCSF, San Francisco, California, USA.; Clinical Cancer Genomics Laboratory, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Grenert+JP%22">Grenert JP</searchLink>; Department of Pathology, UCSF, San Francisco, California, USA.; Clinical Cancer Genomics Laboratory, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22van+Ziffle+J%22">van Ziffle J</searchLink>; Department of Pathology, UCSF, San Francisco, California, USA.; Clinical Cancer Genomics Laboratory, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Talevich+E%22">Talevich E</searchLink>; Clinical Cancer Genomics Laboratory, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Onodera+C%22">Onodera C</searchLink>; Clinical Cancer Genomics Laboratory, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Aboian+M%22">Aboian M</searchLink>; Department of Radiology, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Cha+S%22">Cha S</searchLink>; Department of Radiology, UCSF, San Francisco, California, USA.; Department of Neurological Surgery, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Raleigh+DR%22">Raleigh DR</searchLink>; Department of Radiation Oncology, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Braunstein+S%22">Braunstein S</searchLink>; Department of Radiation Oncology, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Torkildson+J%22">Torkildson J</searchLink>; Division of Pediatric Hematology/Oncology, UCSF Benioff Children's Hospital Oakland,Oakland, California, USA.<br /><searchLink fieldCode="AU" term="%22Samuel+D%22">Samuel D</searchLink>; Division of Pediatric Hematology/Oncology, Valley Children's Hospital, Madera, California, USA.<br /><searchLink fieldCode="AU" term="%22Bloomer+M%22">Bloomer M</searchLink>; Department of Ophthalmology, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Campomanes+AGA%22">Campomanes AGA</searchLink>; Department of Ophthalmology, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Banerjee+A%22">Banerjee A</searchLink>; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California San Francisco (UCSF), San Francisco, California, USA.; Department of Neurological Surgery, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Butowski+N%22">Butowski N</searchLink>; Division of Neuro-Oncology, Department of Neurological Surgery, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Raffel+C%22">Raffel C</searchLink>; Department of Neurological Surgery, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Tihan+T%22">Tihan T</searchLink>; Department of Pathology, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Bollen+AW%22">Bollen AW</searchLink>; Department of Pathology, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Phillips+JJ%22">Phillips JJ</searchLink>; Department of Pathology, UCSF, San Francisco, California, USA.; Department of Neurological Surgery, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Korn+WM%22">Korn WM</searchLink>; Divisions of Gastroenterology and Medical Oncology, Department of Medicine, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Yeh+I%22">Yeh I</searchLink>; Department of Pathology, UCSF, San Francisco, California, USA.; Clinical Cancer Genomics Laboratory, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Bastian+BC%22">Bastian BC</searchLink>; Department of Pathology, UCSF, San Francisco, California, USA.; Clinical Cancer Genomics Laboratory, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Gupta+N%22">Gupta N</searchLink>; Department of Neurological Surgery, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Mueller+S%22">Mueller S</searchLink>; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California San Francisco (UCSF), San Francisco, California, USA.; Department of Neurological Surgery, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Perry+A%22">Perry A</searchLink>; Department of Pathology, UCSF, San Francisco, California, USA.; Department of Neurological Surgery, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Nicolaides+T%22">Nicolaides T</searchLink>; Division of Pediatric Hematology/Oncology, Department of Pediatrics, University of California San Francisco (UCSF), San Francisco, California, USA.; Department of Neurological Surgery, UCSF, San Francisco, California, USA.<br /><searchLink fieldCode="AU" term="%22Solomon+DA%22">Solomon DA</searchLink>; Department of Pathology, UCSF, San Francisco, California, USA.; Clinical Cancer Genomics Laboratory, UCSF, San Francisco, California, USA.
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