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Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal.

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Title: Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal.
Authors: Yan KS; Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.; Columbia Center for Human Development, Department of Medicine, Division of Digestive and Liver Diseases, Department of Genetics and Development, Columbia University Medical Center, New York 10032, USA., Janda CY; Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA., Chang J; Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA., Zheng GXY; 10x Genomics, Inc., Pleasanton, California 94566, USA., Larkin KA; Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA., Luca VC; Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA., Chia LA; Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA., Mah AT; Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA., Han A; Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.; Columbia Center for Translational Immunology, Department of Medicine, Division of Digestive and Liver Diseases, Department of Microbiology and Immunology, Columbia University Medical Center, New York 10032, USA., Terry JM; 10x Genomics, Inc., Pleasanton, California 94566, USA., Ootani A; Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA., Roelf K; Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA., Lee M; Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA., Yuan J; Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA., Li X; Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA., Bolen CR; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, USA., Wilhelmy J; Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA., Davies PS; Oregon Health &Science University, Department of Cell, Developmental and Cancer Biology, Portland, Oregon 97239, USA., Ueno H; Institute for Stem Cell Biology, Stanford University School of Medicine, Stanford, California 94305, USA., von Furstenberg RJ; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Belgrader P; 10x Genomics, Inc., Pleasanton, California 94566, USA., Ziraldo SB; 10x Genomics, Inc., Pleasanton, California 94566, USA., Ordonez H; 10x Genomics, Inc., Pleasanton, California 94566, USA., Henning SJ; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA., Wong MH; Oregon Health &Science University, Department of Cell, Developmental and Cancer Biology, Portland, Oregon 97239, USA., Snyder MP; Department of Genetics, Stanford University School of Medicine, Stanford, California 94305, USA., Weissman IL; Institute for Stem Cell Biology, Stanford University School of Medicine, Stanford, California 94305, USA., Hsueh AJ; Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305, USA., Mikkelsen TS; 10x Genomics, Inc., Pleasanton, California 94566, USA., Garcia KC; Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA., Kuo CJ; Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.
Source: Nature [Nature] 2017 May 11; Vol. 545 (7653), pp. 238-242. Date of Electronic Publication: 2017 May 03.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Non-equivalence of Wnt and R-spondin ligands during Lgr5<superscript>+</superscript> intestinal stem-cell self-renewal.
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Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.<br /><searchLink fieldCode="AU" term="%22Davies+PS%22">Davies PS</searchLink>; Oregon Health &Science University, Department of Cell, Developmental and Cancer Biology, Portland, Oregon 97239, USA.<br /><searchLink fieldCode="AU" term="%22Ueno+H%22">Ueno H</searchLink>; Institute for Stem Cell Biology, Stanford University School of Medicine, Stanford, California 94305, USA.<br /><searchLink fieldCode="AU" term="%22von+Furstenberg+RJ%22">von Furstenberg RJ</searchLink>; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.<br /><searchLink fieldCode="AU" term="%22Belgrader+P%22">Belgrader P</searchLink>; 10x Genomics, Inc., Pleasanton, California 94566, USA.<br /><searchLink fieldCode="AU" term="%22Ziraldo+SB%22">Ziraldo SB</searchLink>; 10x Genomics, Inc., Pleasanton, California 94566, USA.<br /><searchLink fieldCode="AU" term="%22Ordonez+H%22">Ordonez H</searchLink>; 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10x Genomics, Inc., Pleasanton, California 94566, USA.<br /><searchLink fieldCode="AU" term="%22Garcia+KC%22">Garcia KC</searchLink>; Department of Molecular and Cellular Physiology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, California 94305, USA.<br /><searchLink fieldCode="AU" term="%22Kuo+CJ%22">Kuo CJ</searchLink>; Department of Medicine, Stanford University School of Medicine, Stanford, California 94305, USA.
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