Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors.
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| Title: | Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors. |
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| Authors: | McCoull W; IMED Oncology and Discovery Sciences, AstraZeneca , 310 Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, U.K., Abrams RD; IMED Oncology, AstraZeneca , Mereside, Alderley Park, Macclesfield, SK10 4TG, U.K., Anderson E; IMED Oncology and Discovery Sciences, AstraZeneca , Gatehouse Park, Waltham, Massachusetts 02451, United States., Blades K; IMED Oncology, AstraZeneca , Mereside, Alderley Park, Macclesfield, SK10 4TG, U.K., Barton P; IMED Oncology and Discovery Sciences, AstraZeneca , 310 Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, U.K., Box M; IMED Oncology, AstraZeneca , Mereside, Alderley Park, Macclesfield, SK10 4TG, U.K., Burgess J; IMED Oncology, AstraZeneca , Mereside, Alderley Park, Macclesfield, SK10 4TG, U.K., Byth K; IMED Oncology and Discovery Sciences, AstraZeneca , Gatehouse Park, Waltham, Massachusetts 02451, United States., Cao Q; IMED Oncology and Discovery Sciences, AstraZeneca , Gatehouse Park, Waltham, Massachusetts 02451, United States., Chuaqui C; IMED Oncology and Discovery Sciences, AstraZeneca , Gatehouse Park, Waltham, Massachusetts 02451, United States., Carbajo RJ; IMED Oncology and Discovery Sciences, AstraZeneca , 310 Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, U.K., Cheung T; IMED Oncology and Discovery Sciences, AstraZeneca , Gatehouse Park, Waltham, Massachusetts 02451, United States., Code E; IMED Oncology and Discovery Sciences, AstraZeneca , Gatehouse Park, Waltham, Massachusetts 02451, United States., Ferguson AD; IMED Oncology and Discovery Sciences, AstraZeneca , Gatehouse Park, Waltham, Massachusetts 02451, United States., Fillery S; IMED Oncology and Discovery Sciences, AstraZeneca , 310 Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, U.K., Fuller NO; IMED Oncology and Discovery Sciences, AstraZeneca , Gatehouse Park, Waltham, Massachusetts 02451, United States., Gangl E; IMED Oncology and Discovery Sciences, AstraZeneca , Gatehouse Park, Waltham, Massachusetts 02451, United States., Gao N; IMED Oncology and Discovery Sciences, AstraZeneca , Gatehouse Park, Waltham, Massachusetts 02451, United States., Grist M; IMED Oncology, AstraZeneca , Mereside, Alderley Park, Macclesfield, SK10 4TG, U.K., Hargreaves D; IMED Oncology and Discovery Sciences, AstraZeneca , 310 Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, U.K., Howard MR; IMED Oncology and Discovery Sciences, AstraZeneca , 310 Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, U.K., Hu J; IMED Oncology and Discovery Sciences, AstraZeneca , Gatehouse Park, Waltham, Massachusetts 02451, United States., Kemmitt PD; IMED Oncology and Discovery Sciences, AstraZeneca , 310 Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, U.K., Nelson JE; IMED Oncology, AstraZeneca , Mereside, Alderley Park, Macclesfield, SK10 4TG, U.K., O'Connell N; IMED Oncology and Discovery Sciences, AstraZeneca , Gatehouse Park, Waltham, Massachusetts 02451, United States., Prince DB; IMED Oncology and Discovery Sciences, AstraZeneca , Gatehouse Park, Waltham, Massachusetts 02451, United States., Raubo P; IMED Oncology and Discovery Sciences, AstraZeneca , 310 Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, U.K., Rawlins PB; IMED Oncology and Discovery Sciences, AstraZeneca , 310 Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, U.K., Robb GR; IMED Oncology and Discovery Sciences, AstraZeneca , 310 Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, U.K., Shi J; Pharmaron Beijing Co., Ltd. 6 Taihe Road BDA, Beijing 100176 P. R. China., Waring MJ; IMED Oncology, AstraZeneca , Mereside, Alderley Park, Macclesfield, SK10 4TG, U.K., Whittaker D; IMED Oncology, AstraZeneca , Mereside, Alderley Park, Macclesfield, SK10 4TG, U.K., Wylot M; IMED Oncology and Discovery Sciences, AstraZeneca , 310 Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, U.K., Zhu X; IMED Oncology and Discovery Sciences, AstraZeneca , Gatehouse Park, Waltham, Massachusetts 02451, United States. |
| Source: | Journal of medicinal chemistry [J Med Chem] 2017 May 25; Vol. 60 (10), pp. 4386-4402. Date of Electronic Publication: 2017 May 09. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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