Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action.
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| Title: | Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action. |
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| Authors: | Steinman JB; Laboratory of Chemistry and Cell Biology, Rockefeller University, New York, United States., Santarossa CC; Laboratory of Chemistry and Cell Biology, Rockefeller University, New York, United States., Miller RM; Laboratory of Chemistry and Cell Biology, Rockefeller University, New York, United States., Yu LS; Laboratory of Chemistry and Cell Biology, Rockefeller University, New York, United States., Serpinskaya AS; Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, United States., Furukawa H; Tri-Institutitional Therapeutics Discovery Institute, New York, United States., Morimoto S; Tri-Institutitional Therapeutics Discovery Institute, New York, United States., Tanaka Y; Tri-Institutitional Therapeutics Discovery Institute, New York, United States., Nishitani M; Pharmaceutical Research Division, Takeda Pharmaceuticals Ltd, Kanagawa, Japan., Asano M; Tri-Institutitional Therapeutics Discovery Institute, New York, United States., Zalyte R; Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom., Ondrus AE; Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, United States., Johnson AG; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, United States., Ye F; Department of Molecular and Cellular Physiology, Stanford University, Stanford, United States., Nachury MV; Department of Molecular and Cellular Physiology, Stanford University, Stanford, United States., Fukase Y; Tri-Institutitional Therapeutics Discovery Institute, New York, United States., Aso K; Tri-Institutitional Therapeutics Discovery Institute, New York, United States., Foley MA; Tri-Institutitional Therapeutics Discovery Institute, New York, United States., Gelfand VI; Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, United States., Chen JK; Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, United States., Carter AP; Medical Research Council Laboratory of Molecular Biology, Cambridge, United Kingdom., Kapoor TM; Laboratory of Chemistry and Cell Biology, Rockefeller University, New York, United States. |
| Source: | ELife [Elife] 2017 May 19; Vol. 6. Date of Electronic Publication: 2017 May 19. |
| Publication Type: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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