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Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers.

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Title: Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers.
Authors: Bialucha CU; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts. carl_uli.bialucha@novartis.com., Collins SD; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Li X; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Saxena P; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Zhang X; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Dürr C; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, Switzerland., Lafont B; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, Switzerland., Prieur P; Novartis Institutes for Biomedical Research, Novartis Campus, Basel, Switzerland., Shim Y; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Mosher R; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Lee D; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Ostrom L; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Hu T; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Bilic S; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Rajlic IL; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Capka V; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Jiang W; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Wagner JP; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Elliott G; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Veloso A; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Piel JC; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Flaherty MM; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Mansfield KG; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Meseck EK; Novartis Institutes for Biomedical Research, East Hanover, New Jersey., Rubic-Schneider T; Novartis Institutes for Biomedical Research, Campus Klybeckstrasse, Basel, Switzerland., London AS; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Tschantz WR; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Kurz M; Novartis Pharma AG, Novartis Campus, Basel, Switzerland., Nguyen D; Novartis Pharma, Cambridge, Massachusetts., Bourret A; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Meyer MJ; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Faris JE; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Janatpour MJ; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Chan VW; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Yoder NC; ImmunoGen Inc., Waltham, Massachusetts., Catcott KC; ImmunoGen Inc., Waltham, Massachusetts., McShea MA; ImmunoGen Inc., Waltham, Massachusetts., Sun X; ImmunoGen Inc., Waltham, Massachusetts., Gao H; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Williams J; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Hofmann F; Novartis Institutes for Biomedical Research, Campus Klybeckstrasse, Basel, Switzerland., Engelman JA; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Ettenberg SA; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Sellers WR; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts., Lees E; Novartis Institutes for Biomedical Research, Cambridge, Massachusetts.
Source: Cancer discovery [Cancer Discov] 2017 Sep; Vol. 7 (9), pp. 1030-1045. Date of Electronic Publication: 2017 May 19.
Publication Type: Journal Article
Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
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  Data: Discovery and Optimization of HKT288, a Cadherin-6-Targeting ADC for the Treatment of Ovarian and Renal Cancers.
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  Data: <searchLink fieldCode="JN" term="%22101561693%22">Cancer discovery</searchLink> [Cancer Discov] 2017 Sep; Vol. 7 (9), pp. 1030-1045. <i>Date of Electronic Publication: </i>2017 May 19.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+Cancer+Research%22">American Association for Cancer Research </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101561693 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2159-8290 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2221598274%22">21598274 </searchLink><i>NLM ISO Abbreviation: </i>Cancer Discov <i>Subsets: </i>MEDLINE
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