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Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women.

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Title: Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women.
Authors: Klatt NR; Department of Pharmaceutics, Washington National Primate Research Center, University of Washington, Seattle, WA, USA. adam.burgener@umanitoba.ca klattnr@uw.edu., Cheu R; Department of Pharmaceutics, Washington National Primate Research Center, University of Washington, Seattle, WA, USA., Birse K; National HIV and Retrovirology Labs, J.C. Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada., Zevin AS; Department of Pharmaceutics, Washington National Primate Research Center, University of Washington, Seattle, WA, USA., Perner M; National HIV and Retrovirology Labs, J.C. Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada., Noël-Romas L; National HIV and Retrovirology Labs, J.C. Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada., Grobler A; Centre for the AIDS Program of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa., Westmacott G; Mass Spectrometry and Proteomics Core Facility, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada., Xie IY; National HIV and Retrovirology Labs, J.C. Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada., Butler J; National HIV and Retrovirology Labs, J.C. Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada., Mansoor L; Centre for the AIDS Program of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa., McKinnon LR; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada.; Centre for the AIDS Program of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa., Passmore JS; Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town and National Health Laboratory Service, Cape Town, South Africa.; Centre for the AIDS Program of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa., Abdool Karim Q; Centre for the AIDS Program of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, NY, USA., Abdool Karim SS; Centre for the AIDS Program of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, NY, USA., Burgener AD; National HIV and Retrovirology Labs, J.C. Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada. adam.burgener@umanitoba.ca klattnr@uw.edu.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada.; Unit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
Source: Science (New York, N.Y.) [Science] 2017 Jun 02; Vol. 356 (6341), pp. 938-945.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
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  Data: Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women.
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  Data: <searchLink fieldCode="AU" term="%22Klatt+NR%22">Klatt NR</searchLink>; Department of Pharmaceutics, Washington National Primate Research Center, University of Washington, Seattle, WA, USA. adam.burgener@umanitoba.ca klattnr@uw.edu.<br /><searchLink fieldCode="AU" term="%22Cheu+R%22">Cheu R</searchLink>; Department of Pharmaceutics, Washington National Primate Research Center, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Birse+K%22">Birse K</searchLink>; National HIV and Retrovirology Labs, J.C. Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Zevin+AS%22">Zevin AS</searchLink>; Department of Pharmaceutics, Washington National Primate Research Center, University of Washington, Seattle, WA, USA.<br /><searchLink fieldCode="AU" term="%22Perner+M%22">Perner M</searchLink>; National HIV and Retrovirology Labs, J.C. Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Noël-Romas+L%22">Noël-Romas L</searchLink>; National HIV and Retrovirology Labs, J.C. Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Grobler+A%22">Grobler A</searchLink>; Centre for the AIDS Program of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Westmacott+G%22">Westmacott G</searchLink>; Mass Spectrometry and Proteomics Core Facility, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Xie+IY%22">Xie IY</searchLink>; National HIV and Retrovirology Labs, J.C. Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Butler+J%22">Butler J</searchLink>; National HIV and Retrovirology Labs, J.C. Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada.<br /><searchLink fieldCode="AU" term="%22Mansoor+L%22">Mansoor L</searchLink>; Centre for the AIDS Program of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22McKinnon+LR%22">McKinnon LR</searchLink>; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada.; Centre for the AIDS Program of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Passmore+JS%22">Passmore JS</searchLink>; Institute of Infectious Diseases and Molecular Medicine (IDM), University of Cape Town and National Health Laboratory Service, Cape Town, South Africa.; Centre for the AIDS Program of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.<br /><searchLink fieldCode="AU" term="%22Abdool+Karim+Q%22">Abdool Karim Q</searchLink>; Centre for the AIDS Program of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, NY, USA.<br /><searchLink fieldCode="AU" term="%22Abdool+Karim+SS%22">Abdool Karim SS</searchLink>; Centre for the AIDS Program of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, NY, USA.<br /><searchLink fieldCode="AU" term="%22Burgener+AD%22">Burgener AD</searchLink>; National HIV and Retrovirology Labs, J.C. Wilt Infectious Diseases Research Centre, Public Health Agency of Canada, Winnipeg, Manitoba, Canada. adam.burgener@umanitoba.ca klattnr@uw.edu.; Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada.; Unit of Infectious Diseases, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden.
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