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Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells.

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Title: Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells.
Authors: Genini D; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Brambilla L; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.; Molecular Oncology and Immunology Program, New York University School of Medicine, New York, NY 10016., Laurini E; Molecular Simulation Engineering Laboratory, University of Trieste, 34127 Trieste, Italy., Merulla J; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Civenni G; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Pandit S; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., D'Antuono R; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Perez L; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Levy DE; Molecular Oncology and Immunology Program, New York University School of Medicine, New York, NY 10016., Pricl S; Molecular Simulation Engineering Laboratory, University of Trieste, 34127 Trieste, Italy., Carbone GM; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Catapano CV; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland; carlo.catapano@ior.iosi.ch.; Department of Oncology, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Jun 20; Vol. 114 (25), pp. E4924-E4933. Date of Electronic Publication: 2017 Jun 05.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells.
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  Data: <searchLink fieldCode="AU" term="%22Genini+D%22">Genini D</searchLink>; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Brambilla+L%22">Brambilla L</searchLink>; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.; Molecular Oncology and Immunology Program, New York University School of Medicine, New York, NY 10016.<br /><searchLink fieldCode="AU" term="%22Laurini+E%22">Laurini E</searchLink>; Molecular Simulation Engineering Laboratory, University of Trieste, 34127 Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Merulla+J%22">Merulla J</searchLink>; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Civenni+G%22">Civenni G</searchLink>; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Pandit+S%22">Pandit S</searchLink>; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22D'Antuono+R%22">D'Antuono R</searchLink>; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Perez+L%22">Perez L</searchLink>; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Levy+DE%22">Levy DE</searchLink>; Molecular Oncology and Immunology Program, New York University School of Medicine, New York, NY 10016.<br /><searchLink fieldCode="AU" term="%22Pricl+S%22">Pricl S</searchLink>; Molecular Simulation Engineering Laboratory, University of Trieste, 34127 Trieste, Italy.<br /><searchLink fieldCode="AU" term="%22Carbone+GM%22">Carbone GM</searchLink>; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.<br /><searchLink fieldCode="AU" term="%22Catapano+CV%22">Catapano CV</searchLink>; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland; carlo.catapano@ior.iosi.ch.; Department of Oncology, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2017 Jun 20; Vol. 114 (25), pp. E4924-E4933. <i>Date of Electronic Publication: </i>2017 Jun 05.
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