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Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells.

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Bibliographic Details
Title: Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells.
Authors: Genini D; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Brambilla L; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland.; Molecular Oncology and Immunology Program, New York University School of Medicine, New York, NY 10016., Laurini E; Molecular Simulation Engineering Laboratory, University of Trieste, 34127 Trieste, Italy., Merulla J; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Civenni G; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Pandit S; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., D'Antuono R; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Perez L; Institute for Research in Biomedicine, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Levy DE; Molecular Oncology and Immunology Program, New York University School of Medicine, New York, NY 10016., Pricl S; Molecular Simulation Engineering Laboratory, University of Trieste, 34127 Trieste, Italy., Carbone GM; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland., Catapano CV; Tumor Biology and Experimental Therapeutics Program, Institute of Oncology Research, Università della Svizzera Italiana, 6500 Bellinzona, Switzerland; carlo.catapano@ior.iosi.ch.; Department of Oncology, Faculty of Biology and Medicine, University of Lausanne, 1015 Lausanne, Switzerland.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Jun 20; Vol. 114 (25), pp. E4924-E4933. Date of Electronic Publication: 2017 Jun 05.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1091-6490
DOI:10.1073/pnas.1615730114