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Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery.

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Title: Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery.
Authors: Rees HA; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA., Komor AC; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA., Yeh WH; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA.; Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA.; Program in Speech and Hearing Bioscience and Technology, Harvard Medical School, Boston, Massachusetts 02115, USA., Caetano-Lopes J; Orthopaedic Research Laboratories, Boston Children's Hospital, Boston, Massachusetts 02215, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02215, USA., Warman M; Orthopaedic Research Laboratories, Boston Children's Hospital, Boston, Massachusetts 02215, USA.; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02215, USA., Edge ASB; Eaton-Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA.; Program in Speech and Hearing Bioscience and Technology, Harvard Medical School, Boston, Massachusetts 02115, USA.; Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02115, USA., Liu DR; Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.; Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02141, USA.
Source: Nature communications [Nat Commun] 2017 Jun 06; Vol. 8, pp. 15790. Date of Electronic Publication: 2017 Jun 06.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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