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Single-molecule analysis of ligand efficacy in β2AR-G-protein activation.

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Title: Single-molecule analysis of ligand efficacy in β2AR-G-protein activation.
Authors: Gregorio GG; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA., Masureel M; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, USA., Hilger D; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, USA., Terry DS; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA., Juette M; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA., Zhao H; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA., Zhou Z; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA., Perez-Aguilar JM; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA., Hauge M; Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA.; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York, USA.; Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 3, Copenhagen 2200, Denmark.; NNF Center for Basic Metabolic Research, University of Copenhagen, Blegdamsvej 3, Copenhagen 2200, Denmark., Mathiasen S; Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA.; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York, USA., Javitch JA; Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA.; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York, USA.; Department of Pharmacology, Columbia University College of Physicians and Surgeons, New York, New York, USA., Weinstein H; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College of Cornell University, New York, New York, USA., Kobilka BK; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, USA., Blanchard SC; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA.
Source: Nature [Nature] 2017 Jul 06; Vol. 547 (7661), pp. 68-73. Date of Electronic Publication: 2017 Jun 07.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: Single-molecule analysis of ligand efficacy in β<subscript>2</subscript>AR-G-protein activation.
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  Data: <searchLink fieldCode="AU" term="%22Gregorio+GG%22">Gregorio GG</searchLink>; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Masureel+M%22">Masureel M</searchLink>; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Hilger+D%22">Hilger D</searchLink>; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Terry+DS%22">Terry DS</searchLink>; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Juette+M%22">Juette M</searchLink>; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Zhao+H%22">Zhao H</searchLink>; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+Z%22">Zhou Z</searchLink>; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Perez-Aguilar+JM%22">Perez-Aguilar JM</searchLink>; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Hauge+M%22">Hauge M</searchLink>; Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA.; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York, USA.; Laboratory for Molecular Pharmacology, Department of Neuroscience and Pharmacology, University of Copenhagen, Blegdamsvej 3, Copenhagen 2200, Denmark.; NNF Center for Basic Metabolic Research, University of Copenhagen, Blegdamsvej 3, Copenhagen 2200, Denmark.<br /><searchLink fieldCode="AU" term="%22Mathiasen+S%22">Mathiasen S</searchLink>; Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA.; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Javitch+JA%22">Javitch JA</searchLink>; Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA.; Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, New York, USA.; Department of Pharmacology, Columbia University College of Physicians and Surgeons, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Weinstein+H%22">Weinstein H</searchLink>; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA.; The HRH Prince Alwaleed Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine, Weill Cornell Medical College of Cornell University, New York, New York, USA.<br /><searchLink fieldCode="AU" term="%22Kobilka+BK%22">Kobilka BK</searchLink>; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California, USA.<br /><searchLink fieldCode="AU" term="%22Blanchard+SC%22">Blanchard SC</searchLink>; Department of Physiology and Biophysics, Weill Cornell Medicine, New York, New York, USA.
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  Data: <searchLink fieldCode="JN" term="%220410462%22">Nature</searchLink> [Nature] 2017 Jul 06; Vol. 547 (7661), pp. 68-73. <i>Date of Electronic Publication: </i>2017 Jun 07.
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