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Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide.

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Title: Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide.
Authors: Swaminathan S; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Birudukota S; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Thakur MK; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Parveen R; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Kandan S; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Juluri S; Department of Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Shaik S; Department of Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Anand NN; Department of Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Burri RR; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Kristam R; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Hallur MS; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Rajagopal S; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India., Schreuder H; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany., Langer T; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany., Rudolph C; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany., Ruf S; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany., Dhakshinamoorthy S; Department of Biology, Jubilant Biosys Ltd, Bangalore 560022, India., Gosu R; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India. Electronic address: ramachandraiah_gosu@jubilantbiosys.com., Kannt A; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany; Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2017 Sep 16; Vol. 491 (2), pp. 416-422. Date of Electronic Publication: 2017 Jul 15.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE
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  Data: Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide.
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  Data: <searchLink fieldCode="AU" term="%22Swaminathan+S%22">Swaminathan S</searchLink>; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Birudukota+S%22">Birudukota S</searchLink>; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Thakur+MK%22">Thakur MK</searchLink>; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Parveen+R%22">Parveen R</searchLink>; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Kandan+S%22">Kandan S</searchLink>; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Juluri+S%22">Juluri S</searchLink>; Department of Biology, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Shaik+S%22">Shaik S</searchLink>; Department of Biology, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Anand+NN%22">Anand NN</searchLink>; Department of Biology, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Burri+RR%22">Burri RR</searchLink>; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Kristam+R%22">Kristam R</searchLink>; Department of Computational Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Hallur+MS%22">Hallur MS</searchLink>; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Rajagopal+S%22">Rajagopal S</searchLink>; Department of Medicinal Chemistry, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Schreuder+H%22">Schreuder H</searchLink>; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Langer+T%22">Langer T</searchLink>; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Rudolph+C%22">Rudolph C</searchLink>; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Ruf+S%22">Ruf S</searchLink>; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany.<br /><searchLink fieldCode="AU" term="%22Dhakshinamoorthy+S%22">Dhakshinamoorthy S</searchLink>; Department of Biology, Jubilant Biosys Ltd, Bangalore 560022, India.<br /><searchLink fieldCode="AU" term="%22Gosu+R%22">Gosu R</searchLink>; Department of Structural Biology, Jubilant Biosys Ltd, Bangalore 560022, India. Electronic address: ramachandraiah_gosu@jubilantbiosys.com.<br /><searchLink fieldCode="AU" term="%22Kannt+A%22">Kannt A</searchLink>; Sanofi Research and Development, Industriepark Hoechst, H823, D-65926 Frankfurt am Main, Germany; Institute of Experimental and Clinical Pharmacology and Toxicology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
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